ASB3 - ankyrin repeat and SOCS box containing 3 Gene

Also Known as ASB-3

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 51130

About ASB3

Cytogenetic location: 2p16.2 Genomic coordinates (GRCh38): 2:53,669,980-53,786,953 (from NCBI)

This gene has 16 transcripts (splice variants), 197 orthologues and 7 paralogues. Ubiquitous expression in brain (RPKM 8.4), testis (RPKM 6.9) and 25 other tissues.

Summary

The protein encoded by this gene is a member of the ankyrin repeat and SOCS box-containing (ASB) family of proteins. They contain ankyrin repeat sequence and SOCS box domain. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly targeting them for degradation. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Jan 2011]

ASB3 Products (3)

mRNA	Protein	Name
NM_001201965.2	NP_001188894.1	ankyrin repeat and SOCS box protein 3 isoform b
NM_016115.5	NP_057199.1	ankyrin repeat and SOCS box protein 3 isoform a
NM_145863.3	NP_665862.1	ankyrin repeat and SOCS box protein 3 isoform b

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25814554	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ASB3 Protein Structure

Ank_2

Ank_4

Ank_2

SOCS_box

0
100
200
300
400
518 a.a.

Protein Preferred Names	Protein Names
ankyrin repeat and SOCS box protein 3

Related Diseases

Diseases	Alias
Neuronitis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01068	ASB3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	ASB3	VGNC	VGNC:108201
Rattus norvegicus	ASB3	RGD	RGD:1308462
Mus musculus	ASB3	MGD	MGI:1929749
Others	ASB3	NCBI