ASB3 - ankyrin repeat and SOCS box containing 3 Gene

Homo sapiens

Also known as ASB-3

Gene ID: 51130 | Gene type: protein coding

About ASB3

Cytogenetic location: 2p16.2 Genomic coordinates (GRCh38): 2:53,669,980-53,786,953 (from NCBI)

This gene has 16 transcripts (splice variants), 197 orthologues and 7 paralogues. Ubiquitous expression in brain (RPKM 8.4), testis (RPKM 6.9) and 25 other tissues.

Summary

The protein encoded by this gene is a member of the ankyrin repeat and SOCS box-containing (ASB) family of proteins. They contain ankyrin repeat sequence and SOCS box domain. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly targeting them for degradation. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Jan 2011]

ASB3 Products(3)

mRNA	Protein	Name
NM_001201965.2	NP_001188894.1	ankyrin repeat and SOCS box protein 3 isoform b
NM_016115.5	NP_057199.1	ankyrin repeat and SOCS box protein 3 isoform a
NM_145863.3	NP_665862.1	ankyrin repeat and SOCS box protein 3 isoform b

ASB3 Protein Structure

Ank_2

Ank_4

Ank_2

SOCS_box

0
100
200
300
400
518 a.a.

Protein Preferred Names

Protein Names

ankyrin repeat and SOCS box protein 3

Related Diseases

Diseases

Alias

Neuronitis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01068	ASB3 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	ASB3	VGNC	VGNC:108201
Rattus norvegicus	ASB3	RGD	RGD:1308462
Mus musculus	ASB3	MGD	MGI:1929749