PHF11 - PHD finger protein 11 Gene

Also Known as APY; BCAP; IGEL; IGER; IGHER; NYREN34; NY-REN-34

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 51131

About PHF11

Cytogenetic location: 13q14.2 Genomic coordinates (GRCh38): 13:49,495,953-49,528,992 (from NCBI)

This gene has 18 transcripts (splice variants), 133 orthologues and 3 paralogues. Ubiquitous expression in lymph node (RPKM 13.0), spleen (RPKM 12.7) and 25 other tissues.

Summary

This gene encodes a protein containing a PHD (plant homeodomain) type zinc finger. This gene has been identified in some studies as a candidate gene for asthma. Naturally-occurring readthrough transcription may occur from the upstream SETDB2 (SET domain bifurcated 2) gene to this locus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]

PHF11 Products (2)

mRNA Protein Name
NM_001040443.3 NP_001035533.1 PHD finger protein 11 isoform a
NM_001040444.2 NP_001035534.1 PHD finger protein 11 isoform b

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PHF11 Protein Structure

zf-HC5HC2H

zf-HC5HC2H: PHD-like zinc-binding domain (68 - 160)

  • 0
  • 100
  • 200
  • 300
  • 331 a.a.
Protein Preferred Names Protein Names

PHD finger protein 11

  • BRCA1 C-terminus-associated protein

Related Diseases

Diseases Alias
Asthma

  • Chronic Obstructive Asthma

  • Asthma, Diminished Response To Antileukotriene Treatment In

  • Bronchial Hyperreactivity

  • Asthma, Susceptibility To

  • Asthma, Bronchial

  • Asthma, Protection Against

  • Asthma, Nocturnal, Susceptibility To

  • Nocturnal Asthma

  • Asthma-Related Traits

  • Asthma-Related Traits, Susceptibility To

  • Asthma, Nocturnal

  • Chronic Obstructive Asthma With Acute Exacerbation

  • Chronic Obstructive Asthma With Status Asthmaticus

  • Exercise Induced Asthma

  • Exercise-Induced Asthma

  • Bronchial Asthma

  • Asthma, Exercise-Induced

  • Idiosyncratic Asthma

  • Unspecified Asthma With Acute Exacerbation

  • Asthma, Unspecified, With Stated Status Asthmaticus

  • Status Asthmaticus Nos

  • Acute Severe Asthma

  • Acute Severe Bronchial Asthma

  • Status Asthma

  • Status Post Asthmaticus
Near-Fatal Asthma
Ige Responsiveness, Atopic

  • ATOPY

  • Atopy, Susceptibility To

  • Ige, Elevated Level Of

  • IGER

  • Immunoglobulin E, Basic Level Of, In Serum

  • Ige, Level Of

  • Igel

  • Ige Response Underlying Allergic Asthma And Rhinitis

  • Atopic Hypersensitivity

  • Immediate Hypersensitivity
Dermatitis, Atopic

  • Atopic Dermatitis

  • Atopic Eczema

  • Dermatitis, Atopic, Susceptibility To, 1

  • Atod

  • Eczema, Atopic

  • Dermatitis, Atopic 1

  • Allergic Dermatitis

  • Atopic Neurodermatitis

  • Besnier'S Prurigo

  • Dermatitis, Atopic, 1

  • Dermatitis Atopic

  • Eczema

  • Besnier Prurigo
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10415 PHF11 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus PHF11 VGNC VGNC:104698
Bos taurus PHF11 VGNC VGNC:106864
Canis familiaris PHF11 VGNC VGNC:44481
Rattus norvegicus PHF11 RGD RGD:1310853
Macaca mulatta PHF11 VGNC VGNC:75814
Others PHF11 NCBI