CRIM1 - cysteine rich transmembrane BMP regulator 1 Gene

Also Known as S52; CRIM-1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 51232

About CRIM1

Cytogenetic location: 2p22.2 Genomic coordinates (GRCh38): 2:36,355,778-36,551,135 (from NCBI)

This gene has 8 transcripts (splice variants), 1 gene allele, 133 orthologues, 19 paralogues and is associated with 2 phenotypes. Broad expression in placenta (RPKM 93.7), fat (RPKM 55.7) and 23 other tissues.

Summary

This gene encodes a transmembrane protein containing six cysteine-rich repeat domains and an insulin-like growth factor-binding domain. The encoded protein may play a role in tissue development though interactions with members of the transforming growth factor beta family, such as bone morphogenetic proteins. [provided by RefSeq, Nov 2010]

CRIM1 Products (1)

mRNA Protein Name
NM_016441.3 NP_057525.1 cysteine-rich motor neuron 1 protein precursor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables PDZ domain binding IDA
IDA: Inferred from direct assay
23209302 GOA
Biological Process GO Annotation Evidence References Source
acts upstream of or within negative regulation of BMP signaling pathway IMP
IMP: Inferred from mutant phenotype
21743293 GOA
acts upstream of negative regulation of osteoblast differentiation IMP
IMP: Inferred from mutant phenotype
21042576 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CRIM1 Protein Structure

VWC

VWC: von Willebrand factor type C domain (336 - 390)

VWC

VWC: von Willebrand factor type C domain (403 - 456)

Antistasin

Antistasin: Antistasin family (469 - 498)

Antistasin

Antistasin: Antistasin family (505 - 532)

Antistasin

Antistasin: Antistasin family (539 - 564)

Antistasin

Antistasin: Antistasin family (567 - 592)

VWC

VWC: von Willebrand factor type C domain (611 - 662)

VWC

VWC: von Willebrand factor type C domain (684 - 734)

VWC

VWC: von Willebrand factor type C domain (757 - 808)

VWC

VWC: von Willebrand factor type C domain (819 - 873)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1036 a.a.
Protein Preferred Names Protein Names

cysteine-rich motor neuron 1 protein

  • cysteine rich transmembrane BMP regulator 1 (chordin-like)

Related Diseases

Diseases Alias
Macrophthalmia, Colobomatous, With Microcornea

  • MACOM

  • Colobomatous Macrophthalmia-Microcornea Syndrome

  • Macom Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03174 CRIM1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21541 Crim1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28059 Crim1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus CRIM1 VGNC VGNC:27710
Mus musculus CRIM1 MGD MGI:1354756
Felis catus CRIM1 VGNC VGNC:61178
Canis familiaris CRIM1 VGNC VGNC:39612
Macaca mulatta CRIM1 VGNC VGNC:106144
Rattus norvegicus CRIM1 RGD RGD:1308710
Others CRIM1 NCBI