NGRN - neugrin, neurite outgrowth associated Gene

Also Known as DSC92

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 51335

About NGRN

Cytogenetic location: 15q26.1 Genomic coordinates (GRCh38): 15:90,265,663-90,272,211 (from NCBI)

This gene has 3 transcripts (splice variants) and 168 orthologues. Ubiquitous expression in brain (RPKM 111.2), prostate (RPKM 60.9) and 25 other tissues.

Summary

Enables rRNA binding activity. Involved in positive regulation of mitochondrial translation. Located in several cellular components, including intercellular bridge; mitotic spindle; and nuclear body. [provided by Alliance of Genome Resources, Apr 2022]

NGRN Products (1)

mRNA Protein Name
NM_001033088.3 NP_001028260.2 neugrin precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
enables rRNA binding IDA
IDA: Inferred from direct assay
27667664 GOA
Biological Process GO Annotation Evidence References Source
involved in mitochondrial ribosome assembly IMP
IMP: Inferred from mutant phenotype
27667664 GOA
involved in positive regulation of mitochondrial translation IMP
IMP: Inferred from mutant phenotype
27667664 GOA
Cellular Component GO Annotation Evidence References Source
located in mitochondrial membrane IDA
IDA: Inferred from direct assay
27667664 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NGRN Protein Structure

Neugrin

Neugrin: Neugrin (73 - 291)

  • 0
  • 100
  • 200
  • 291 a.a.
Protein Preferred Names Protein Names

neugrin

  • mesenchymal stem cell protein DSC92

Related Diseases

Diseases Alias
Deafness, Autosomal Dominant 16

  • DFNA16

  • Autosomal Dominant Nonsyndromic Deafness 16

  • Autosomal Dominant Deafness 16
Deafness, Autosomal Dominant 18

  • DFNA18

  • Autosomal Dominant Nonsyndromic Deafness 18

  • Autosomal Dominant Deafness 18
Deafness, Autosomal Recessive 27

  • DFNB27

  • Autosomal Recessive Nonsyndromic Deafness 27

  • Autosomal Recessive Deafness 27
Deafness, Autosomal Dominant 27

  • DFNA27

  • Autosomal Dominant Nonsyndromic Deafness 27

  • Autosomal Dominant Deafness 27

  • Deafness, Autosomal Dominant, 27
Camptodactyly-Arthropathy-Coxa Vara-Pericarditis Syndrome

  • Jacobs Syndrome

  • Arthropathy-Camptodactyly Syndrome

  • Pericarditis-Arthropathy-Camptodactyly Syndrome

  • Xyy Syndrome

  • Pac Syndrome

  • Cacp Syndrome

  • CACP

  • Fibrosing Serositis, Familial

  • Camptodactyly-Arthropathy-Pericarditis Syndrome

  • Cap Syndrome

  • 47, Xyy Syndrome

  • 47,Xyy Syndrome

  • Double Y Syndrome

  • Camptodactyly-Arthropathy-Coxa-Vara-Pericarditis Syndrome

  • Hypertrophic Synovitis, Congenital Familial

  • Congenital Familial Hypertrophic Synovitis

  • Xyy Karyotype

  • Y Disomy

  • Yy Syndrome

  • Familial Fibrosing Serositis

  • Disomy Y

  • Double Y

  • Camptodactyly Arthropathy Coxa Vara Pericarditis Syndrome

  • Arthropathy Camptodactyly Syndrome

  • Camptodactyly Arthropathy Pericarditis Syndrome

  • Pericarditis Arthropathy Camptodactyly Syndrome

  • Jacob'S Syndrome

  • 47,Xyy

  • Cdags Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09280 NGRN Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus NGRN MGD MGI:1933212
Felis catus NGRN VGNC VGNC:80900
Rattus norvegicus NGRN RGD RGD:1583734
Bos taurus NGRN VGNC VGNC:57159
Canis familiaris NGRN VGNC VGNC:59024
Others NGRN NCBI