ZC3HC1 - zinc finger C3HC-type containing 1 Gene

Also Known as NIPA; HSPC216

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 51530

About ZC3HC1

Cytogenetic location: 7q32.2 Genomic coordinates (GRCh38): 7:130,018,286-130,051,451 (from NCBI)

This gene has 12 transcripts (splice variants) and 208 orthologues. Ubiquitous expression in testis (RPKM 3.8), lymph node (RPKM 2.0) and 25 other tissues.

Summary

This gene encodes an F-box-containing protein that is a component of an SCF-type E3 ubiquitin Ligase complex that regulates the onset of cell division. The G2/M transition in the cell cycle requires the interaction of the proteins cyclin B1 and cyclin-dependent kinase 1. The activated ubiquitin Ligase complex targets the protein cyclin B1 for degradation, preventing this transition to Mitosis. [provided by RefSeq, Aug 2013]

ZC3HC1 Products (4)

mRNA Protein Name
NM_001282190.2 NP_001269119.1 zinc finger C3HC-type protein 1 isoform 2
NM_001282191.1 NP_001269120.1 zinc finger C3HC-type protein 1 isoform 3
NM_001363701.1 NP_001350630.1 zinc finger C3HC-type protein 1 isoform 4
NM_016478.5 NP_057562.3 zinc finger C3HC-type protein 1 isoform 1

ZC3HC1 Protein Structure

zf-C3HC

zf-C3HC: C3HC zinc finger-like (73 - 199)

Rsm1

Rsm1: Rsm1-like (248 - 332)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 502 a.a.
Protein Preferred Names Protein Names

zinc finger C3HC-type protein 1

nuclear-interacting partner of ALK

  • hematopoietic stem/progenitor cell protein 216

Related Diseases

Diseases Alias
Immunodeficiency 30

  • Mendelian Susceptibility To Mycobacterial Diseases Due To Complete Il12rb1 Deficiency

  • IMD30

  • Il12rb1 Deficiency

  • Mendelian Susceptibility To Interleukin 12 Receptor Beta 1 Deficiency

  • Msmd Due To Complete Il12rb1 Deficiency

  • Msmd Due To Complete Interleukin 12 Receptor Beta 1 Deficiency

  • Il-12râ1 Deficiency

  • Mendelian Susceptibility To Mycobacterial Infections Due To Il12 Deficiency

  • Immunodeficiency, Type 30
Fanconi Anemia, Complementation Group A

  • Fanconi Anemia

  • Fanconi Pancytopenia

  • Fanconi Anemia Complementation Group A

  • FANCA

  • Fa

  • Fanconi Panmyelopathy

  • Fanconi'S Anemia

  • Fanconi Anaemia

  • Fanconi'S Anaemia

  • Fanconi Hypoplastic Anemia

  • Estren-Dameshek Variant Of Fanconi Anemia

  • Estren-Dameshek Variant Of Fanconi Pancytopenia

  • Fanconi Anemia Estren-Dameshek Variant

  • Fanconis Anemia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15998 ZC3HC1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus ZC3HC1 MGD MGI:1916023
Felis catus ZC3HC1 VGNC VGNC:67192
Macaca mulatta ZC3HC1 VGNC VGNC:79827
Rattus norvegicus ZC3HC1 RGD RGD:1561099
Bos taurus ZC3HC1 VGNC VGNC:37113
Others ZC3HC1 NCBI