SIX4 - SIX homeobox 4 Gene

Also Known as AREC3

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 51804

About SIX4

Cytogenetic location: 14q23.1 Genomic coordinates (GRCh38): 14:60,709,539-60,724,351 (from NCBI)

This gene has 3 transcripts (splice variants), 225 orthologues and 6 paralogues. Broad expression in prostate (RPKM 2.0), salivary gland (RPKM 1.8) and 16 other tissues.

Summary

This gene encodes a member of the homeobox family, subfamily SIX. The drosophila homolog is a nuclear homeoprotein required for eye development. Studies in mouse show that this gene product functions as a transcription factor, and may have a role in the differentiation or maturation of neuronal cells. [provided by RefSeq, May 2010]

SIX4 Products (1)

mRNA Protein Name
NM_017420.5 NP_059116.3 homeobox protein SIX4

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables sequence-specific double-stranded DNA binding IDA
IDA: Inferred from direct assay
28473536 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SIX4 Protein Structure

Homeobox

Homeobox: Homeobox domain (230 - 279)

  • 0
  • 200
  • 400
  • 600
  • 781 a.a.
Protein Preferred Names Protein Names

homeobox protein SIX4

  • sine oculis homeobox homolog 4

Related Diseases

Diseases Alias
Branchiootic Syndrome

  • Bo Syndrome

  • Branchiootic Dysplasia

  • Bor

  • Bo Syndrome 1

  • Bos1

  • Branchiootic Syndrome 1
Bardet-Biedl Syndrome 8

  • BBS8

  • Bardet-Biedl Syndrome, Type 8
Branchiootorenal Syndrome

  • Branchio-Oto-Renal Syndrome

  • Bor Syndrome

  • Branchiootorenal Dysplasia

  • Melnick-Fraser Syndrome

  • Branchiootorenal Spectrum Disorders

  • Branchio-Otorenal Dysplasia

  • Branchio Oto Renal Syndrome

  • Branchiootorenal/Branchiootic Syndrome

  • Bo Syndrome

  • Bor

  • Bos

  • Branchio-Otorenal Syndrome

  • Branchiootic Syndrome

  • Branchiootorenal Syndrome

  • Branchiootic Syndrome 1
Paralytic Squint

  • Paralytic Strabismus

  • Incomitant Dissociation
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12961 SIX4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21434 Six4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27952 Six4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris SIX4 VGNC VGNC:46192
Mus musculus SIX4 MGD MGI:106034
Felis catus SIX4 VGNC VGNC:80845
Macaca mulatta SIX4 VGNC VGNC:99240
Bos taurus SIX4 VGNC VGNC:109396
Rattus norvegicus SIX4 RGD RGD:1306726
Others SIX4 NCBI