Nus1 - NUS1 dehydrodolichyl diphosphate synthase subunit Gene

Mus musculus

Also known as D10Ertd438e; 1600027K07Rik

Gene ID: 52014 | Gene type: protein coding

About Nus1

Summary

Enables prenyltransferase activity. Acts upstream of or within Cholesterol homeostasis; protein mannosylation; and regulation of intracellular Cholesterol transport. Located in membrane. Human ortholog(s) of this gene implicated in autosomal dominant mental retardation 55 and congenital disorder of glycosylation Iaa. Orthologous to human NUS1 (NUS1 dehydrodolichyl diphosphate synthase subunit). [provided by Alliance of Genome Resources, Apr 2022]

Nus1 Products(1)

mRNA	Protein	Name
NM_030250.2	NP_084526.1	dehydrodolichyl diphosphate synthase complex subunit Nus1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables prenyltransferase activity	IMP IMP: Inferred from mutant phenotype	25066056	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within cholesterol homeostasis	IMP IMP: Inferred from mutant phenotype	25066056	MGI
acts upstream of or within protein mannosylation	IMP IMP: Inferred from mutant phenotype	25066056	MGI
acts upstream of or within regulation of intracellular cholesterol transport	IMP IMP: Inferred from mutant phenotype	19723497	MGI
acts upstream of or within sterol homeostasis	IMP IMP: Inferred from mutant phenotype	19723497	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in membrane	IMP IMP: Inferred from mutant phenotype	25066056	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

dehydrodolichyl diphosphate synthase complex subunit Nus1

Nogo-B receptor	dehydrodolichyl diphosphate syntase complex subunit Nus1
di-trans,poly-cis-decaprenylcistransferase	ngBR
nuclear undecaprenyl pyrophosphate synthase 1 homolog

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09703	NUS1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Nus1	NCBI	NCBI:116150

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