Slc46a1 - solute carrier family 46, member 1 Gene

Also Known as HCP1; Pcft; D11Ertd18e; 1110002C08Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 52466

Summary

Enables heme transmembrane transporter activity. Involved in heme transport. Located in apical plasma membrane and cytoplasm. Is expressed in adrenal gland; metanephros; spinal cord; and testis. Human ortholog(s) of this gene implicated in hereditary folate malabsorption. Orthologous to human SLC46A1 (solute carrier family 46 member 1). [provided by Alliance of Genome Resources, Apr 2022]

Slc46a1 Products (1)

mRNA Protein Name
NM_026740.2 NP_081016.2 proton-coupled folate transporter

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables folic acid:proton symporter activity IDA
IDA: Inferred from direct assay
17962486 MGI
enables heme transmembrane transporter activity IDA
IDA: Inferred from direct assay
16143108 MGI
enables methotrexate transmembrane transporter activity IDA
IDA: Inferred from direct assay
17962486 MGI
Biological Process GO Annotation Evidence References Source
involved in folate import across plasma membrane IDA
IDA: Inferred from direct assay
17962486 MGI
involved in heme transport IDA
IDA: Inferred from direct assay
16143108 MGI
Cellular Component GO Annotation Evidence References Source
located in apical plasma membrane IDA
IDA: Inferred from direct assay
16143108 MGI
is active in basolateral plasma membrane IDA
IDA: Inferred from direct assay
19074442 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
16143108 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

proton-coupled folate transporter

  • PCFT/HCP1

  • heme carrier protein 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13260 SLC46A1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Slc46a1 NCBI NCBI:113235