2. Gene
  3. Slx4 - SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae) Gene

Slx4 - SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae) Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Btbd12; D16Bwg1016e

Gene ID: 52864 | Gene type: protein coding

About Slx4

Summary

This gene encodes a protein containing a BTB (POZ) domain that comprises a subunit of structure-specific endonucleases. The encoded protein aids in the resolution of DNA secondary structures that arise during the processes of DNA repair and recombination. Knock out of this gene in mouse recapitulates the phenotype of the human disease Fanconi anemia, including blood cytopenia and susceptibility to genomic instability. [provided by RefSeq, Dec 2013]

Slx4 Products(9)

mRNA Protein Name
NM_001402923.1 NP_001389852.1 structure-specific endonuclease subunit SLX4 isoform 2
NM_001402924.1 NP_001389853.1 structure-specific endonuclease subunit SLX4 isoform 2
NM_001402925.1 NP_001389854.1 structure-specific endonuclease subunit SLX4 isoform 2
NM_001402926.1 NP_001389855.1 structure-specific endonuclease subunit SLX4 isoform 3
NM_001402927.1 NP_001389856.1 structure-specific endonuclease subunit SLX4 isoform 4
NM_001402928.1 NP_001389857.1 structure-specific endonuclease subunit SLX4 isoform 4
NM_001402930.1 NP_001389859.1 structure-specific endonuclease subunit SLX4 isoform 4
NM_001402931.1 NP_001389860.1 structure-specific endonuclease subunit SLX4 isoform 4
NM_177472.5 NP_803423.2 structure-specific endonuclease subunit SLX4 isoform 1
Gene Ontology
  • Biological Process
Biological Process GO Annotation Evidence Reference Source
involved in positive regulation of t-circle formation IMP
IMP: Inferred from mutant phenotype
22579284 MGI
involved in t-circle formation IMP
IMP: Inferred from mutant phenotype
22579284 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

structure-specific endonuclease subunit SLX4

BTB/POZ domain-containing protein 12

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS13389 SLX4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS13390 SLX4IP Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Slx4 NCBI NCBI:84464