CLIC5 - chloride intracellular channel 5 Gene

Homo sapiens

Also known as MST130; DFNB102; DFNB103; MSTP130

Gene ID: 53405 | Gene type: protein coding

About CLIC5

Cytogenetic location: 6p21.1 Genomic coordinates (GRCh38): 6:45,880,827-46,129,819 (from NCBI)

This gene has 14 transcripts (splice variants), 242 orthologues, 14 paralogues and is associated with 2 phenotypes. Biased expression in lung (RPKM 21.7), heart (RPKM 20.0) and 10 other tissues.

Summary

This gene encodes a member of the chloride intracellular channel (CLIC) family of chloride ion channels. The encoded protein associates with actin-based cytoskeletal structures and may play a role in multiple processes including hair cell stereocilia formation, myoblast proliferation and glomerular podocyte and endothelial cell maintenance. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]

CLIC5 Products(5)

mRNA	Protein	Name
NM_001114086.2	NP_001107558.1	chloride intracellular channel protein 5 isoform a
NM_001256023.2	NP_001242952.1	chloride intracellular channel protein 5 isoform c
NM_001370649.1	NP_001357578.1	chloride intracellular channel protein 5 isoform d
NM_001370650.1	NP_001357579.1	chloride intracellular channel protein 5 isoform a
NM_016929.5	NP_058625.2	chloride intracellular channel protein 5 isoform b

CLIC5 Protein Structure

GST_N_3

0
100
200
300
410 a.a.

Protein Preferred Names

Protein Names

chloride intracellular channel protein 5

Recombinant CLIC5 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70113	CLIC5 Protein, Human (His)	Q9NZA1-2 (P173-S410)	≥95%

Related Diseases

Diseases

Alias

Deafness, Autosomal Recessive 103

DFNB103	Autosomal Recessive Nonsyndromic Deafness 103
Autosomal Recessive Deafness 103	Deafness, Autosomal Recessive, 103
Deafness, Autosomal Recessive, Type 103

Autosomal Recessive Non-Syndromic Sensorineural Deafness Type Dfnb

Autosomal Recessive Isolated Neurosensory Deafness Type Dfnb	Autosomal Recessive Isolated Neurosensory Hearing Loss Type Dfnb
Autosomal Recessive Isolated Sensorineural Deafness Type Dfnb	Autosomal Recessive Isolated Sensorineural Hearing Loss Type Dfnb
Autosomal Recessive Non-Syndromic Neurosensory Deafness Type Dfnb	Autosomal Recessive Non-Syndromic Neurosensory Hearing Loss Type Dfnb
Autosomal Recessive Non-Syndromic Sensorineural Hearing Loss Type Dfnb

Autosomal Recessive Nonsyndromic Deafness

Deafness, Autosomal Recessive, Nonsyndromic

Deafness, Autosomal Recessive

Retinitis Pigmentosa 20

RP20	Retinitis Pigmentosa, Type 20

Ischemic Neuropathy

Ischemic Peripheral Neuropathy

Retinitis Pigmentosa 25

RP25	Retinitis Pigmentosa-25
Retinitis Pigmentosa, Type 25

Deafness, Autosomal Recessive 102

DFNB102	Autosomal Recessive Nonsyndromic Deafness 102
Autosomal Recessive Deafness 102	Deafness, Autosomal Recessive, 102
Deafness, Autosomal Recessive, Type 102

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02807	CLIC5 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	CLIC5	VGNC	VGNC:102402
Canis familiaris	CLIC5	VGNC	VGNC:39341
Macaca mulatta	CLIC5	VGNC	VGNC:71171
Rattus norvegicus	CLIC5	RGD	RGD:620659
Mus musculus	CLIC5	MGD	MGI:1917912
Bos taurus	CLIC5	VGNC	VGNC:107286
Others	CLIC5	NCBI

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