GPR85 - G protein-coupled receptor 85 Gene

Also Known as SREB; SREB2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 54329

About GPR85

Cytogenetic location: 7q31.1 Genomic coordinates (GRCh38): 7:113,082,285-113,087,724 (from NCBI)

This gene has 7 transcripts (splice variants), 197 orthologues and 2 paralogues. Biased expression in brain (RPKM 3.3), testis (RPKM 1.1) and 12 other tissues.

Summary

Members of the G protein-coupled receptor (GPCR) family, such as GPR85, have a similar structure characterized by 7 transmembrane domains. Activation of GPCRs by extracellular stimuli, such as neurotransmitters, Hormones, or light, induces an intracellular signaling cascade mediated by heterotrimeric GTP-binding proteins, or G proteins (Matsumoto et al., 2000 [PubMed 10833454]).[supplied by OMIM, Aug 2008]

GPR85 Products (4)

mRNA Protein Name
NM_001146265.2 NP_001139737.1 probable G-protein coupled receptor 85
NM_001146266.2 NP_001139738.1 probable G-protein coupled receptor 85
NM_001146267.2 NP_001139739.1 probable G-protein coupled receptor 85
NM_018970.7 NP_061843.3 probable G-protein coupled receptor 85

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
25780553 GOA
Cellular Component GO Annotation Evidence References Source
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
25780553 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GPR85 Protein Structure

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (37 - 338)

  • 0
  • 100
  • 200
  • 300
  • 370 a.a.
Protein Preferred Names Protein Names

probable G-protein coupled receptor 85

  • seven transmembrane helix receptor

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05741 GPR85 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20944 Gpr85 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27461 Gpr85 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus GPR85 VGNC VGNC:67445
Canis familiaris GPR85 VGNC VGNC:41447
Bos taurus GPR85 VGNC VGNC:29602
Mus musculus GPR85 MGD MGI:1927851
Macaca mulatta GPR85 VGNC VGNC:73147
Rattus norvegicus GPR85 RGD RGD:71011
Others GPR85 NCBI