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DNAJC10 - DnaJ heat shock protein family (Hsp40) member C10 Gene

Also Known as JPDI; MTHr; ERdj5; PDIA19

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 54431

About DNAJC10

Cytogenetic location: 2q32.1 Genomic coordinates (GRCh38): 2:182,716,257-182,794,464 (from NCBI)

This gene has 24 transcripts (splice variants), 219 orthologues and 20 paralogues. Ubiquitous expression in endometrium (RPKM 35.6), thyroid (RPKM 29.7) and 25 other tissues.

Summary

This gene encodes an endoplasmic reticulum co-chaperone which is part of the endoplasmic reticulum-associated degradation complex involved in recognizing and degrading misfolded proteins. The encoded protein reduces incorrect disulfide bonds in misfolded glycoproteins. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2012]

DNAJC10 Products (2)

mRNA	Protein	Name
NM_001271581.3	NP_001258510.1	dnaJ homolog subfamily C member 10 isoform 2
NM_018981.4	NP_061854.1	dnaJ homolog subfamily C member 10 isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Verweise	Source
enables ATPase binding	IPI IPI: Inferred from physical interaction	12411443	GOA
enables Hsp70 protein binding	IPI IPI: Inferred from physical interaction	23769672	GOA
enables misfolded protein binding	IDA IDA: Inferred from direct assay	18400946	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	19706418	GOA
enables protein-disulfide reductase activity	IDA IDA: Inferred from direct assay	23769672	GOA
enables protein-folding chaperone binding	IDA IDA: Inferred from direct assay	12411443	GOA

Biological Process GO Annotation	Evidence	Verweise	Source
involved in ERAD pathway	IMP IMP: Inferred from mutant phenotype	18400946	GOA
involved in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	IDA IDA: Inferred from direct assay	19122239	GOA
involved in negative regulation of protein phosphorylation	IDA IDA: Inferred from direct assay	19122239	GOA
involved in protein folding in endoplasmic reticulum	IDA IDA: Inferred from direct assay	23769672	GOA
involved in response to endoplasmic reticulum stress	IDA IDA: Inferred from direct assay	19122239	GOA

Cellular Component GO Annotation	Evidence	Verweise	Source
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	12411443	GOA
part of endoplasmic reticulum chaperone complex	IDA IDA: Inferred from direct assay	18400946	GOA
located in endoplasmic reticulum lumen	IDA IDA: Inferred from direct assay	23769672	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DNAJC10 Protein Structure

DnaJ

Thioredoxin

0
200
400
600
793 a.a.

Protein Preferred Names	Protein Names
dnaJ homolog subfamily C member 10	DnaJ (Hsp40) homolog, subfamily C, member 10

Related Diseases

Diseases	Alias
Seminal Vesicle Tumor	Tumor Of Seminal Vesicle Seminal Vesicle Neoplasm Seminal Vesicle Tumour Tumour Of Seminal Vesicle
Cutis Laxa, Autosomal Dominant 1	Cutis Laxa, Autosomal Dominant Autosomal Dominant Cutis Laxa ADCL1 Adcl Autosomal Dominant Cutis Laxa 1 Cutis Laxa, Autosomal Dominant, 1 Cutis Laxa, Autosomal Dominant, Type 1
Parkinson Disease, Late-Onset	Parkinson Disease Parkinson'S Disease PD PARK Parkinson Disease, Susceptibility To Late Onset Parkinson'S Disease Late Onset Parkinson Disease Paralysis Agitans Primary Parkinsonism Idiopathic Parkinson Disease Parkinson'S Parkinson Disease, Late-Onset, Susceptibility To Parkinson Disease, Age Of Onset, Modifier Lewy Body Parkinson Disease Idiopathic Parkinson'S Disease Pd - [Parkinson Disease] Parkinson Disease Nos Parkinson, Nos Primary Parkinson Disease

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-RS03873	DNAJC10 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	DNAJC10	VGNC	VGNC:53092
Macaca mulatta	DNAJC10	VGNC	VGNC:84229
Bos taurus	DNAJC10	VGNC	VGNC:49056
Felis catus	DNAJC10	VGNC	VGNC:80184
Mus musculus	DNAJC10	MGD	MGI:1914111
Rattus norvegicus	DNAJC10	RGD	RGD:1307813
Others	DNAJC10	NCBI