DHX29 - DExH-box helicase 29 Gene

Homo sapiens

Also known as DDX29

Gene ID: 54505 | Gene type: protein coding

About DHX29

Cytogenetic location: 5q11.2 Genomic coordinates (GRCh38): 5:55,256,055-55,307,694 (from NCBI)

This gene has 4 transcripts (splice variants), 207 orthologues and 18 paralogues. Ubiquitous expression in thyroid (RPKM 12.7), prostate (RPKM 10.7) and 25 other tissues.

Summary

This gene encodes a member of the DEAH (Asp-Glu-Ala-His) subfamily of proteins, part of the DEAD (Asp-Glu-Ala-Asp) box family of RNA helicases. The encoded protein functions in translation initiation, and is specifically required for ribosomal scanning across stable mRNA secondary structures during initiation codon selection. This protein may also play a role in sensing virally derived cytosolic nucleic acids. Knockdown of this gene results in reduced protein translation and impaired proliferation of Cancer cells. [provided by RefSeq, Sep 2016]

DHX29 Products(3)

mRNA	Protein	Name
NM_001345964.2	NP_001332893.1	ATP-dependent RNA helicase DHX29 isoform 2
NM_001345965.2	NP_001332894.1	ATP-dependent RNA helicase DHX29 isoform 3 precursor
NM_019030.4	NP_061903.2	ATP-dependent RNA helicase DHX29 isoform 1

DHX29 Protein Structure

DEAD

Helicase_C

HA2

OB_NTP_bind

0
300
600
900
1200
1369 a.a.

Protein Preferred Names

Protein Names

ATP-dependent RNA helicase DHX29

DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 29

Related Diseases

Diseases

Alias

Chromosome 22q11.2 Deletion Syndrome, Distal

22q11.2 Deletion Syndrome	Autosomal Dominant Opitz G/Bbb Syndrome
Catch22	Cayler Cardiofacial Syndrome
Conotruncal Anomaly Face Syndrome	Digeorge Syndrome
Sedlackova Syndrome	Shprintzen Syndrome
Velocardiofacial Syndrome	22q11.2 Distal Deletion Syndrome
Distal 22q11.2 Microdeletion Syndrome	22q11.2ds
Vcfs	Velo-Cardio-Facial Syndrome
Distal Chromosome 22q11.2 Deletion Syndrome	Chromosome 22q11.2 Deletion Syndrome Distal
Chromosome 22q11.2 Deletion Syndrome	Deletion 22q11.2 Syndrome
22q11ds	Catch 22
Digeorge Sequence	Microdeletion 22q11.2
Monosomy 22q11	Takao Syndrome
Distal Del(22)(Q11.2)	Distal Monosomy 22q11.2
Catch 22 Syndrome	Chromosome Deletion Syndrome 22q11.2, Distal

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03750	DHX29 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	DHX29	MGD	MGI:2145374
Canis familiaris	DHX29	VGNC	VGNC:39941
Felis catus	DHX29	VGNC	VGNC:61476
Macaca mulatta	DHX29	VGNC	VGNC:71627
Rattus norvegicus	DHX29	RGD	RGD:2318361
Bos taurus	DHX29	VGNC	VGNC:28050

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