DHX29 - DExH-box helicase 29 Gene

Also Known as DDX29

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 54505

About DHX29

Cytogenetic location: 5q11.2 Genomic coordinates (GRCh38): 5:55,256,055-55,307,694 (from NCBI)

This gene has 4 transcripts (splice variants), 207 orthologues and 18 paralogues. Ubiquitous expression in thyroid (RPKM 12.7), prostate (RPKM 10.7) and 25 other tissues.

Summary

This gene encodes a member of the DEAH (Asp-Glu-Ala-His) subfamily of proteins, part of the DEAD (Asp-Glu-Ala-Asp) box family of RNA helicases. The encoded protein functions in translation initiation, and is specifically required for ribosomal scanning across stable mRNA secondary structures during initiation codon selection. This protein may also play a role in sensing virally derived cytosolic nucleic acids. Knockdown of this gene results in reduced protein translation and impaired proliferation of Cancer cells. [provided by RefSeq, Sep 2016]

DHX29 Products (3)

mRNA Protein Name
NM_001345964.2 NP_001332893.1 ATP-dependent RNA helicase DHX29 isoform 2
NM_001345965.2 NP_001332894.1 ATP-dependent RNA helicase DHX29 isoform 3 precursor
NM_019030.4 NP_061903.2 ATP-dependent RNA helicase DHX29 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables ribonucleoside triphosphate phosphatase activity IMP
IMP: Inferred from mutant phenotype
23047696 GOA
enables ribosomal small subunit binding IDA
IDA: Inferred from direct assay
23706745 GOA
enables translation activator activity IMP
IMP: Inferred from mutant phenotype
20018725 GOA
Biological Process GO Annotation Evidence Verweise Source
involved in formation of translation preinitiation complex IMP
IMP: Inferred from mutant phenotype
23047696 GOA
involved in ribosome assembly IMP
IMP: Inferred from mutant phenotype
20018725 GOA
Cellular Component GO Annotation Evidence Verweise Source
part of cytosolic small ribosomal subunit IDA
IDA: Inferred from direct assay
20018725 GOA
part of eukaryotic 43S preinitiation complex IDA
IDA: Inferred from direct assay
23706745 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DHX29 Protein Structure

DEAD

DEAD: DEAD/DEAH box helicase (580 - 738)

Helicase_C

Helicase_C: Helicase conserved C-terminal domain (896 - 985)

HA2

HA2: Helicase associated domain (HA2) (1048 - 1138)

OB_NTP_bind

OB_NTP_bind: Oligonucleotide/oligosaccharide-binding (OB)-fold (1180 - 1302)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1369 a.a.
Protein Preferred Names Protein Names

ATP-dependent RNA helicase DHX29

  • DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 29

Related Diseases

Diseases Alias
Chromosome 22q11.2 Deletion Syndrome, Distal

  • 22q11.2 Deletion Syndrome

  • Autosomal Dominant Opitz G/Bbb Syndrome

  • Catch22

  • Cayler Cardiofacial Syndrome

  • Conotruncal Anomaly Face Syndrome

  • Digeorge Syndrome

  • Sedlackova Syndrome

  • Shprintzen Syndrome

  • Velocardiofacial Syndrome

  • 22q11.2 Distal Deletion Syndrome

  • Distal 22q11.2 Microdeletion Syndrome

  • 22q11.2ds

  • Vcfs

  • Velo-Cardio-Facial Syndrome

  • Distal Chromosome 22q11.2 Deletion Syndrome

  • Chromosome 22q11.2 Deletion Syndrome Distal

  • Chromosome 22q11.2 Deletion Syndrome

  • Deletion 22q11.2 Syndrome

  • 22q11ds

  • Catch 22

  • Digeorge Sequence

  • Microdeletion 22q11.2

  • Monosomy 22q11

  • Takao Syndrome

  • Distal Del(22)(Q11.2)

  • Distal Monosomy 22q11.2

  • Catch 22 Syndrome

  • Chromosome Deletion Syndrome 22q11.2, Distal
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS03750 DHX29 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22468 Dhx29 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28991 Dhx29 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus DHX29 MGD MGI:2145374
Canis familiaris DHX29 VGNC VGNC:39941
Felis catus DHX29 VGNC VGNC:61476
Macaca mulatta DHX29 VGNC VGNC:71627
Rattus norvegicus DHX29 RGD RGD:2318361
Bos taurus DHX29 VGNC VGNC:28050
Others DHX29 NCBI