PIWIL2 - piwi like RNA-mediated gene silencing 2 Gene

Also Known as CT80; HILI; mili; PIWIL1L

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 55124

About PIWIL2

Cytogenetic location: 8p21.3 Genomic coordinates (GRCh38): 8:22,275,316-22,357,568 (from NCBI)

This gene has 5 transcripts (splice variants), 201 orthologues and 3 paralogues. Biased expression in testis (RPKM 18.7), duodenum (RPKM 3.2) and 2 other tissues.

Summary

PIWIL2 belongs to the Argonaute family of proteins, which function in development and maintenance of germline stem cells (Sasaki et al., 2003 [PubMed 12906857]).[supplied by OMIM, Mar 2008]

PIWIL2 Products (3)

mRNA Protein Name
NM_001135721.3 NP_001129193.1 piwi-like protein 2 isoform 1
NM_001330480.2 NP_001317409.1 piwi-like protein 2 isoform 2
NM_018068.5 NP_060538.2 piwi-like protein 2 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables piRNA binding IDA
IDA: Inferred from direct assay
21193640 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
28903391 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of circadian rhythm IMP
IMP: Inferred from mutant phenotype
28903391 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
28025795 GOA
located in nucleus IDA
IDA: Inferred from direct assay
28025795 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PIWIL2 Protein Structure

PAZ

PAZ: PAZ domain (390 - 524)

Piwi

Piwi: Piwi domain (668 - 956)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 973 a.a.
Protein Preferred Names Protein Names

piwi-like protein 2

  • cancer/testis antigen 80

Related Diseases

Diseases Alias
Male Infertility

  • Infertility, Male

  • Infertility Male

  • Male Sterility

  • Absolute Infertility
Infertility
Spermatogenic Failure

  • Azoospermia

  • Spgf

  • Spermatogenic Failure, Susceptibility To

  • Absent Sperm

  • Aspermatogenesis

  • Infertility Due To Azoospermia

  • Hypospermatogenesis

  • Azoospermatism
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10585 PIWIL2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris PIWIL2 VGNC VGNC:44593
Macaca mulatta PIWIL2 VGNC VGNC:81502
Bos taurus PIWIL2 VGNC VGNC:32928
Felis catus PIWIL2 VGNC VGNC:79363
Mus musculus PIWIL2 MGD MGI:1930036
Rattus norvegicus PIWIL2 RGD RGD:1306964
Others PIWIL2 NCBI