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LGI2 - leucine rich repeat LGI family member 2 Gene

Also Known as LGIL2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 55203

About LGI2

Cytogenetic location: 4p15.2 Genomic coordinates (GRCh38): 4:24,992,081-25,030,946 (from NCBI)

This gene has 2 transcripts (splice variants), 274 orthologues and 22 paralogues. Broad expression in gall bladder (RPKM 3.7), appendix (RPKM 3.2) and 20 other tissues.

Summary

Predicted to be involved in inhibitory synapse assembly. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Apr 2022]

LGI2 Products (1)

mRNA	Protein	Name
NM_018176.4	NP_060646.2	leucine-rich repeat LGI family member 2 precursor

Protein Preferred Names	Protein Names
leucine-rich repeat LGI family member 2	LGI1-like protein 2

Related Diseases

Diseases	Alias
Arthrogryposis Multiplex Congenita-1
Deafness, Autosomal Recessive 98	DFNB98 Autosomal Recessive Nonsyndromic Deafness 98 Autosomal Recessive Deafness 98 Deafness, Autosomal Recessive, 98 Deafness, Autosomal Recessive, Type 98
Epilepsy, Familial Temporal Lobe, 1	ETL1 Adpeaf Adlte Epilepsy, Partial, With Auditory Features Autosomal Dominant Partial Epilepsy With Auditory Features Epilepsy, Lateral Temporal Lobe, Autosomal Dominant Familial Temporal Lobe Epilepsy 1 Partial Epilepsy With Auditory Features Autosomal Dominant Lateral Temporal Lobe Epilepsy Lateral Temporal Lobe Epilepsy Autosomal Dominant Epilepsy, Temporal Lobe, Familial, Type 1
Listeriosis	Listeria Infection Infection By Listeria Monocytogenes Listeria Monocytogenes Infection Listeria Infections Listerial Foodborne Infection Circling Disease Infection Due To Listeria Monocytogenes Listerellosis
Myoclonic Epilepsy Of Lafora	Lafora Disease Epilepsy, Progressive Myoclonic 2b EPM2 Melf Epilepsy, Progressive Myoclonic 2a Epm2a Lafora'S Disease Lafora Body Disease Lbd Epilepsy, Progressive Myoclonic, 2a Lafora Progressive Myoclonic Epilepsy Epilepsy Progressive Myoclonic 2 Lafora Body Disorder Pme Type 2 Progressive Myoclonic Epilepsy Type 2 Progressive Myoclonus Epilepsy Type 2 Epilepsy, Progressive Myoclonic 2 Epm2b Ld Progressive Myoclonic Epilepsy 2 Progressive Myoclonic Epilepsy 2a Progressive Myoclonic Epilepsy 2b Progressive Myoclonic Epilepsy Lafora Type Epilepsy, Myoclonic, Of Lafora
Progressive Myoclonus Epilepsy	Pme Progressive Myoclonic Epilepsy Myoclonic Epilepsies, Progressive Unverricht-Lundborg Syndrome
Benign Familial Infantile Epilepsy	Benign Familial Infantile Seizures Bfie Benign Familial Infantile Convulsion Bfic Bfis Benign Familial Infantile Convulsions Familial Benign Neonatal Epilepsy Watanabe-Vigevano Syndrome
Wolf-Hirschhorn Syndrome	Pitt-Rogers-Danks Syndrome WHS Chromosome 4p16.3 Deletion Syndrome Wittwer Syndrome 4p- Syndrome Pitt Syndrome 4p Deletion Syndrome Distal Deletion 4p Distal Monosomy 4p Telomeric Deletion 4p Prds 4p Syndrome Chromosome 4p Syndrome Microcephaly, Iugr, Hypertelorism, Ptosis, Iris Coloboma, Hooked Nose, External Ear Dysplasia, Psychomotor Retardation Wolf Syndrome Chromosome 4p Deletion Syndrome Chromosome 4p Monosomy Del Syndrome Monosomy 4p Partial Monosomy 4p Chromosome 4 Short Arm Deletion

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07614	LGI2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22219	Lgi2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28741	Lgi2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	LGI2	VGNC	VGNC:78522
Mus musculus	LGI2	MGD	MGI:2180196
Bos taurus	LGI2	VGNC	VGNC:30857
Macaca mulatta	LGI2	VGNC	VGNC:74078
Rattus norvegicus	LGI2	RGD	RGD:1310391
Canis familiaris	LGI2	VGNC	VGNC:49726
Others	LGI2	NCBI