CHFR - checkpoint with forkhead and ring finger domains Gene

Homo sapiens

Also known as RNF116; RNF196

Gene ID: 55743 | Gene type: protein coding

About CHFR

Cytogenetic location: 12q24.33 Genomic coordinates (GRCh38): 12:132,832,356-132,887,618 (from NCBI)

This gene has 24 transcripts (splice variants) and 202 orthologues. Ubiquitous expression in testis (RPKM 9.9), spleen (RPKM 8.8) and 25 other tissues.

Summary

This gene encodes an E3 ubiquitin-protein ligase required for the maintenance of the antephase checkpoint that regulates cell cycle entry into mitosis and, therefore, may play a key role in cell cycle progression and tumorigenesis. The encoded protein has an N-terminal forkhead-associated domain, a central RING-finger domain, and a cysteine-rich C-terminal region. Alternatively spliced transcript variants that encode different protein isoforms have been described. [provided by RefSeq, Mar 2014]

CHFR Products(5)

mRNA	Protein	Name
NM_001161344.1	NP_001154816.1	E3 ubiquitin-protein ligase CHFR isoform 1
NM_001161345.1	NP_001154817.1	E3 ubiquitin-protein ligase CHFR isoform 2
NM_001161346.2	NP_001154818.1	E3 ubiquitin-protein ligase CHFR isoform 3
NM_001161347.1	NP_001154819.1	E3 ubiquitin-protein ligase CHFR isoform 5
NM_018223.2	NP_060693.2	E3 ubiquitin-protein ligase CHFR isoform 4

CHFR Protein Structure

FHA

zf-RING_2

0
200
400
600
664 a.a.

Protein Preferred Names

Protein Names

E3 ubiquitin-protein ligase CHFR

RING finger protein 196

Related Diseases

Diseases

Alias

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02623	CHFR Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	CHFR	RGD	RGD:1306360
Bos taurus	CHFR	VGNC	VGNC:27288
Macaca mulatta	CHFR	VGNC	VGNC:71064
Felis catus	CHFR	VGNC	VGNC:60853
Canis familiaris	CHFR	VGNC	VGNC:39211
Mus musculus	CHFR	MGD	MGI:2444898
Others	CHFR	NCBI