CHFR - checkpoint with forkhead and ring finger domains Gene

Also Known as RNF116; RNF196

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 55743

About CHFR

Cytogenetic location: 12q24.33 Genomic coordinates (GRCh38): 12:132,832,356-132,887,618 (from NCBI)

This gene has 24 transcripts (splice variants) and 202 orthologues. Ubiquitous expression in testis (RPKM 9.9), spleen (RPKM 8.8) and 25 other tissues.

Summary

This gene encodes an E3 ubiquitin-protein Ligase required for the maintenance of the antephase checkpoint that regulates cell cycle entry into Mitosis and, therefore, may play a key role in cell cycle progression and tumorigenesis. The encoded protein has an N-terminal forkhead-associated domain, a central RING-finger domain, and a cysteine-rich C-terminal region. Alternatively spliced transcript variants that encode different protein isoforms have been described. [provided by RefSeq, Mar 2014]

CHFR Products (5)

mRNA Protein Name
NM_001161344.1 NP_001154816.1 E3 ubiquitin-protein ligase CHFR isoform 1
NM_001161345.1 NP_001154817.1 E3 ubiquitin-protein ligase CHFR isoform 2
NM_001161346.2 NP_001154818.1 E3 ubiquitin-protein ligase CHFR isoform 3
NM_001161347.1 NP_001154819.1 E3 ubiquitin-protein ligase CHFR isoform 5
NM_018223.2 NP_060693.2 E3 ubiquitin-protein ligase CHFR isoform 4

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables nucleotide binding IDA
IDA: Inferred from direct assay
18172500 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
15467728 GOA
enables ubiquitin-protein transferase activity IDA
IDA: Inferred from direct assay
18172500 GOA
Biological Process GO Annotation Evidence References Source
involved in meiotic spindle checkpoint signaling IMP
IMP: Inferred from mutant phenotype
10935642 GOA
involved in mitotic G2/M transition checkpoint IMP
IMP: Inferred from mutant phenotype
18172500 GOA
involved in ubiquitin-dependent protein catabolic process IDA
IDA: Inferred from direct assay
19182791 GOA
Cellular Component GO Annotation Evidence References Source
located in PML body IDA
IDA: Inferred from direct assay
15467728 GOA
located in nucleus IDA
IDA: Inferred from direct assay
18172500 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CHFR Protein Structure

FHA

FHA: FHA domain (38 - 105)

zf-RING_2

zf-RING_2: Ring finger domain (303 - 343)

  • 0
  • 200
  • 400
  • 600
  • 664 a.a.
Protein Preferred Names Protein Names

E3 ubiquitin-protein ligase CHFR

  • RING finger protein 196

Related Diseases

Diseases Alias
Colorectal Cancer

  • Colon Cancer

  • Colorectal Carcinoma

  • Colon Carcinoma

  • Colorectal Cancer, Susceptibility To

  • Carcinoma Of Colon

  • CRC

  • Colorectal Cancer With Chromosomal Instability, Somatic

  • Colon Cancer, Somatic

  • Colon Cancer, Susceptibility To

  • Colonic Neoplasms

  • Colorectal Neoplasms

  • Colorectal Cancer, Somatic

  • Colon Cancer, Advanced, Somatic

  • Colonic Carcinoma

  • Colorectal Carcinomas

  • Colon Cancers

  • Colorectal Cancers

  • Cancer, Colorectal, Somatic

  • Cancer, Colon

  • Cancer, Colorectal, Susceptibility To

  • Colorectal Neoplasm

  • Colonic Neoplasm

  • Malignant Tumor Of Colon
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS02623 CHFR Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus CHFR RGD RGD:1306360
Bos taurus CHFR VGNC VGNC:27288
Macaca mulatta CHFR VGNC VGNC:71064
Felis catus CHFR VGNC VGNC:60853
Canis familiaris CHFR VGNC VGNC:39211
Mus musculus CHFR MGD MGI:2444898
Others CHFR NCBI