TRERF1 - transcriptional regulating factor 1 Gene

Also Known as RAPA; BCAR2; TREP132; TReP-132; HSA277276; dJ139D8.5

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 55809

About TRERF1

Cytogenetic location: 6p21.1 Genomic coordinates (GRCh38): 6:42,224,931-42,452,224 (from NCBI)

This gene has 8 transcripts (splice variants), 196 orthologues and 5 paralogues. Ubiquitous expression in testis (RPKM 2.9), bone marrow (RPKM 2.6) and 24 other tissues.

Summary

This gene encodes a zinc-finger transcriptional regulating protein which interacts with CBP/p300 to regulate the human gene CYP11A1. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014]

TRERF1 Products (5)

mRNA Protein Name
NM_001297573.2 NP_001284502.1 transcriptional-regulating factor 1 isoform 1
NM_001391983.1 NP_001378912.1 transcriptional-regulating factor 1 isoform 2
NM_001391984.1 NP_001378913.1 transcriptional-regulating factor 1 isoform 3
NM_001395490.1 NP_001382419.1 transcriptional-regulating factor 1 isoform 4
NM_033502.4 NP_277037.1 transcriptional-regulating factor 1 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables nuclear progesterone receptor binding IPI
IPI: Inferred from physical interaction
17015480 GOA
enables nuclear receptor coactivator activity IDA
IDA: Inferred from direct assay
17015480 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
enables transcription coactivator activity IDA
IDA: Inferred from direct assay
11349124 GOA
enables transcription coactivator binding IPI
IPI: Inferred from physical interaction
11349124 GOA
Biological Process GO Annotation Evidence References Source
involved in cellular response to progesterone stimulus IDA
IDA: Inferred from direct assay
17015480 GOA
involved in positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
11349124 GOA
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
17015480 GOA
involved in progesterone receptor signaling pathway IDA
IDA: Inferred from direct assay
17015480 GOA
Cellular Component GO Annotation Evidence References Source
is active in nucleus IDA
IDA: Inferred from direct assay
11349124 GOA
located in nucleus IDA
IDA: Inferred from direct assay
16371131 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TRERF1 Protein Structure

zf-C2H2_6

zf-C2H2_6: C2H2-type zinc finger (512 - 534)

ELM2

ELM2: ELM2 domain (781 - 836)

zf-C2H2_6

zf-C2H2_6: C2H2-type zinc finger (1019 - 1033)

zf-C2H2_4

zf-C2H2_4: C2H2-type zinc finger (1086 - 1108)

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  • 1200 a.a.
Protein Preferred Names Protein Names

transcriptional-regulating factor 1

  • breast cancer anti-estrogen resistance 2

Related Diseases

Diseases Alias
Estrogen Resistance

  • Estrogen Resistance Syndrome

  • ESTRR

  • Estrogen Insensitivity
Breast Cancer

  • Breast Carcinoma

  • Male Breast Cancer

  • Breast Cancer, Familial

  • Malignant Neoplasm Of Breast

  • Breast Cancer, Susceptibility To

  • Breast Cancer, Early-Onset

  • Malignant Tumor Of Breast

  • Carcinoma Of Male Breast

  • Breast Cancer, Invasive Ductal

  • Breast Cancer, Protection Against

  • Breast Cancer, Somatic

  • Breast Cancer, Male

  • Breast Cancer, Lobular, Somatic

  • Breast Tumor

  • Mammary Cancer

  • Mammary Tumor

  • Malignant Neoplasm Of Male Breast

  • Mammary Carcinoma

  • Male Breast Carcinoma

  • Familial Cancer Of Breast

  • Invasive Ductal Breast Carcinoma

  • Breast Cancer Susceptibility

  • Breast Cancer, Male, Susceptibility To

  • Breast Cancer, Early-Onset, Susceptibility To

  • Malignant Tumor Of The Breast

  • Mammary Neoplasm

  • Primary Breast Cancer

  • Neoplasm Of Male Breast

  • Carcinoma Of Breast

  • Breast Cancer In Men

  • Familial Breast Cancer

  • Cancer Of Breast

  • BC

  • Breast Cancer Familial

  • Breast Cancer Familial Male

  • Breast Cancer, Familial Male

  • Breast Male Carcinoma

  • Breast Neoplasms

  • Breast Neoplasms, Male

  • Mammary Tumors

  • Mammary Carcinomas

  • Cancer, Breast

  • Cancer, Breast, Susceptibility

  • Invasive Breast Ductal Carcinoma

  • Breast Neoplasm

  • Susceptibility To Breast Cancer

  • Mammary Neoplasms

  • Animal Mammary Neoplasms

  • Primary Malignant Neoplasm Of Breast

  • Infiltrating Ductal Carcinoma Of Breast

  • Infiltrating Duct Carcinoma Of Unspecified Site

  • Infiltrating Ductular Carcinoma Of Unspecified Site

  • Invasive Breast Carcinoma Of No Special Type

  • Microinvasive Carcinoma Of Breast

  • Carcinoma With Apocrine Differentiation
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15007 TRERF1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus TRERF1 VGNC VGNC:66521
Canis familiaris TRERF1 VGNC VGNC:47796
Rattus norvegicus TRERF1 RGD RGD:1307167
Macaca mulatta TRERF1 VGNC VGNC:79121
Bos taurus TRERF1 VGNC VGNC:36302
Mus musculus TRERF1 MGD MGI:2442086
Others TRERF1 NCBI