DOK5 - docking protein 5 Gene

Also Known as IRS6; IRS-6; C20orf180

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 55816

About DOK5

Cytogenetic location: 20q13.2 Genomic coordinates (GRCh38): 20:54,475,593-54,651,169 (from NCBI)

This gene has 4 transcripts (splice variants), 143 orthologues and 7 paralogues. Biased expression in brain (RPKM 5.9), heart (RPKM 5.0) and 12 other tissues.

Summary

The protein encoded by this gene is a member of the DOK family of membrane proteins, which are adapter proteins involved in signal transduction. The encoded protein interacts with phosphorylated Receptor Tyrosine Kinases to mediate neurite outgrowth and activation of the MAP kinase pathway. Unlike Other DOK family proteins, this protein does not interact with RASGAP. This protein is up-regulated in patients with systemic sclerosis and is associated with fibrosis induced by insulin-like growth factor binding protein 5. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jun 2014]

DOK5 Products (3)

mRNA Protein Name
NM_001294161.2 NP_001281090.1 docking protein 5 isoform c
NM_018431.5 NP_060901.2 docking protein 5 isoform a
NM_177959.3 NP_808874.1 docking protein 5 isoform b

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Biological Process GO Annotation Evidence References Source
acts upstream of or within regulation of neurotrophin TRK receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
23954828 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DOK5 Protein Structure

IRS

IRS: PTB domain (IRS-1 type) (136 - 230)

  • 0
  • 100
  • 200
  • 306 a.a.
Protein Preferred Names Protein Names

docking protein 5

  • downstream of tyrosine kinase 5

Related Diseases

Diseases Alias
Enterokinase Deficiency

  • Enteropeptidase Deficiency

  • Congenital Enterokinase Deficiency

  • Congenital Enteropathy Due To Enteropeptidase Deficiency

  • Deficiency Of Enteropeptidase

  • ENTKD
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03937 DOK5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus DOK5 RGD RGD:1562846
Bos taurus DOK5 VGNC VGNC:56184
Felis catus DOK5 VGNC VGNC:61584
Canis familiaris DOK5 VGNC VGNC:40059
Macaca mulatta DOK5 VGNC VGNC:71847
Mus musculus DOK5 MGD MGI:1924079
Others DOK5 NCBI