2. Gene
  3. DOK5 - docking protein 5 Gene

DOK5 - docking protein 5 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as IRS6; IRS-6; C20orf180

Gene ID: 55816 | Gene type: protein coding

About DOK5

Cytogenetic location: 20q13.2 Genomic coordinates (GRCh38): 20:54,475,593-54,651,169 (from NCBI)

This gene has 4 transcripts (splice variants), 143 orthologues and 7 paralogues. Biased expression in brain (RPKM 5.9), heart (RPKM 5.0) and 12 other tissues.

Summary

The protein encoded by this gene is a member of the DOK family of membrane proteins, which are adapter proteins involved in signal transduction. The encoded protein interacts with phosphorylated Receptor Tyrosine Kinases to mediate neurite outgrowth and activation of the MAP kinase pathway. Unlike other DOK family proteins, this protein does not interact with RASGAP. This protein is up-regulated in patients with systemic sclerosis and is associated with fibrosis induced by insulin-like growth factor binding protein 5. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jun 2014]

DOK5 Products(3)

mRNA Protein Name
NM_001294161.2 NP_001281090.1 docking protein 5 isoform c
NM_018431.5 NP_060901.2 docking protein 5 isoform a
NM_177959.3 NP_808874.1 docking protein 5 isoform b

DOK5 Protein Structure

IRS

IRS: PTB domain (IRS-1 type) (136 - 230)

  • 0
  • 100
  • 200
  • 306 a.a.
Protein Preferred Names Protein Names

docking protein 5

downstream of tyrosine kinase 5

Related Diseases

Diseases Alias
Enterokinase Deficiency

Enteropeptidase Deficiency

Congenital Enterokinase Deficiency

Congenital Enteropathy Due To Enteropeptidase Deficiency

Deficiency Of Enteropeptidase

ENTKD
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS03937 DOK5 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus DOK5 RGD RGD:1562846
Bos taurus DOK5 VGNC VGNC:56184
Felis catus DOK5 VGNC VGNC:61584
Canis familiaris DOK5 VGNC VGNC:40059
Macaca mulatta DOK5 VGNC VGNC:71847
Mus musculus DOK5 MGD MGI:1924079