KCNQ5 - potassium voltage-gated channel subfamily Q member 5 Gene

Homo sapiens

Also known as Kv7.5; MRD46

Gene ID: 56479 | Gene type: protein coding

About KCNQ5

Cytogenetic location: 6q13 Genomic coordinates (GRCh38): 6:72,622,064-73,198,853 (from NCBI)

This gene has 14 transcripts (splice variants), 280 orthologues, 31 paralogues and is associated with 4 phenotypes. Biased expression in brain (RPKM 8.7), thyroid (RPKM 2.7) and 6 other tissues.

Summary

This gene is a member of the KCNQ Potassium Channel gene family that is differentially expressed in subregions of the brain and in skeletal muscle. The protein encoded by this gene yields currents that activate slowly with depolarization and can form heteromeric channels with the protein encoded by the KCNQ3 gene. Currents expressed from this protein have voltage dependences and inhibitor sensitivities in common with M-currents. They are also inhibited by M1 muscarinic receptor activation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]

KCNQ5 Products(5)

mRNA	Protein	Name
NM_001160130.2	NP_001153602.1	potassium voltage-gated channel subfamily KQT member 5 isoform 2
NM_001160132.2	NP_001153604.1	potassium voltage-gated channel subfamily KQT member 5 isoform 3
NM_001160133.2	NP_001153605.1	potassium voltage-gated channel subfamily KQT member 5 isoform 4
NM_001160134.2	NP_001153606.1	potassium voltage-gated channel subfamily KQT member 5 isoform 5
NM_019842.4	NP_062816.2	potassium voltage-gated channel subfamily KQT member 5 isoform 1

KCNQ5 Protein Structure

Ion_trans

KCNQ_channel

0
200
400
600
800
932 a.a.

Protein Preferred Names

Protein Names

potassium voltage-gated channel subfamily KQT member 5

KQT-like 5

Related Diseases

Diseases

Alias

Intellectual Developmental Disorder, Autosomal Dominant 46

MRD46	Mental Retardation, Autosomal Dominant 46
Autosomal Dominant Mental Retardation 46	Autosomal Dominant Intellectual Developmental Disorder 46
Mental Retardation, Autosomal Dominant, Type 46

Autosomal Dominant Non-Syndromic Intellectual Disability

Benign Neonatal Seizures

Benign Neonatal Epilepsy	Benign Familial Neonatal Seizures
Benign Neonatal Convulsions	Benign Familial Neonatal Convulsions
Benign Familial Neonatal Epilepsy	Bfne
Bfns	Seizures, Benign Neonatal
Neonatal Convulsions Benign	Epilepsy, Benign Neonatal
Epilepsy, Benign Neonatal, 2	Benign Familial Convulsion
Familial Benign Neonatal Epilepsy

Benign Familial Neonatal Epilepsy

Familial Neonatal Seizures	Bfns
Benign Familial Neonatal Convulsions	Benign Familial Neonatal Seizures
Epilepsy Benign Neonatal Familial	Familial Benign Neonatal Convulsions
Benign Neonatal Familial Convulsions	Familial Benign Neonatal Epilepsy
Epilepsy, Benign Neonatal, 2	Benign Familial Convulsion

Myopia

Near-Sightedness	Short-Sightedness
Nearsightedness	Nearsighted
Near Vision	Close Sighted
Myopic	Short-Sighted
Near Sighted

Neonatal Period Electroclinical Syndrome

Long Qt Syndrome 1

Romano-Ward Syndrome	LQT1
Ward-Romano Syndrome	Rws
Ventricular Fibrillation With Prolonged Qt Interval	Wrs
Long Qt Syndrome 1, Acquired, Susceptibility To	Long Qt Syndrome 1, Acquired
Romano-Ward Long Qt Syndrome	Long Qt Syndrome Type 1
Long Qt Syndrome-1	Acquired Susceptibility To Long Qt Syndrome 1
Qt Syndrome, Long, Type 1

Long Qt Syndrome

Romano-Ward Syndrome	Long Q-T Syndrome
Lqt	Qt Syndrome, Long
Congenital Long Qt Syndrome	Familial Long Qt Syndrome

Benign Epilepsy With Centrotemporal Spikes

Rolandic Epilepsy	Benign Rolandic Epilepsy
Epilepsy, Rolandic	Bcects
Benign Childhood Epilepsy With Centrotemporal Spike	Sylvan Seizures
Becrs	Bects
Bre	Benign Epilepsy Of Childhood With Centrotemporal Spikes
Benign Familial Epilepsy Of Childhood With Rolandic Spikes	Centrotemporal Epilepsy

Developmental And Epileptic Encephalopathy

Encephalopathy, Developmental And Epileptic

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-123264	RL648_81	Inhibitor	99.20%	Unkown
HY-RS07177	KCNQ5 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	KCNQ5	VGNC	VGNC:74008
Rattus norvegicus	KCNQ5	RGD	RGD:628848
Canis familiaris	KCNQ5	VGNC	VGNC:42291
Mus musculus	KCNQ5	MGD	MGI:1924937
Bos taurus	KCNQ5	VGNC	VGNC:53795

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