PRDM11 - PR/SET domain 11 Gene

Also Known as PFM8

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 56981

About PRDM11

Cytogenetic location: 11p11.2 Genomic coordinates (GRCh38): 11:45,094,159-45,235,109 (from NCBI)

This gene has 6 transcripts (splice variants), 188 orthologues and 1 paralogue. Ubiquitous expression in thyroid (RPKM 2.3), ovary (RPKM 1.9) and 24 other tissues.

Summary

Predicted to enable chromatin binding activity. Involved in several processes, including negative regulation of cell growth; positive regulation of fibroblast apoptotic process; and regulation of transcription, DNA-templated. Located in cytosol and nucleus. [provided by Alliance of Genome Resources, Apr 2022]

PRDM11 Products (7)

mRNA Protein Name
NM_001256695.2 NP_001243624.1 PR domain-containing protein 11 isoform 1
NM_001256696.2 NP_001243625.1 PR domain-containing protein 11 isoform 2
NM_001359633.2 NP_001346562.2 PR domain-containing protein 11 isoform 2
NM_001384648.1 NP_001371577.1 PR domain-containing protein 11 isoform 1
NM_001384649.1 NP_001371578.1 PR domain-containing protein 11 isoform 4
NM_001384650.1 NP_001371579.1 PR domain-containing protein 11 isoform 4
NM_001384651.1 NP_001371580.1 PR domain-containing protein 11 isoform 4

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
25499759 GOA
involved in negative regulation of cell growth IDA
IDA: Inferred from direct assay
25499759 GOA
involved in positive regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
25499759 GOA
involved in positive regulation of fibroblast apoptotic process IDA
IDA: Inferred from direct assay
25499759 GOA
involved in regulation of MAPK cascade IMP
IMP: Inferred from mutant phenotype
25499759 GOA
involved in regulation of cell cycle IMP
IMP: Inferred from mutant phenotype
25499759 GOA
Cellular Component GO Annotation Evidence References Source
located in cytosol IDA
IDA: Inferred from direct assay
25499759 GOA
located in nucleus IDA
IDA: Inferred from direct assay
25499759 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

PR domain-containing protein 11

  • PR-domain containing protein 11

Related Diseases

Diseases Alias
Eyelid Carcinoma

  • Carcinoma Of The Eyelid
Hermansky-Pudlak Syndrome 1

  • Albinism With Hemorrhagic Diathesis And Pigmented Reticuloendothelial Cells

  • HPS1

  • Delta Storage Pool Disease

  • Albinism With Hemorrhagic Diathesis And Pigmented Reticuloendothelial

  • Hermansky-Pudlak Syndrome, Type 1

  • Platelet Storage Pool Deficiency
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11061 PRDM11 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris PRDM11 VGNC VGNC:54264
Felis catus PRDM11 VGNC VGNC:64344
Mus musculus PRDM11 MGD MGI:2685553
Bos taurus PRDM11 VGNC VGNC:54473
Macaca mulatta PRDM11 VGNC VGNC:76251
Rattus norvegicus PRDM11 RGD RGD:1597330
Others PRDM11 NCBI