ZFYVE28 - zinc finger FYVE-type containing 28 Gene

Also Known as LST2; LYST2; lst-2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 57732

About ZFYVE28

Cytogenetic location: 4p16.3 Genomic coordinates (GRCh38): 4:2,269,597-2,418,645 (from NCBI)

This gene has 11 transcripts (splice variants), 215 orthologues and 13 paralogues. Ubiquitous expression in testis (RPKM 1.1), brain (RPKM 1.1) and 25 other tissues.

Summary

Enables phosphatidylinositol-3-phosphate binding activity. Involved in negative regulation of epidermal growth factor-activated receptor activity. Located in cytosol and early endosome membrane. [provided by Alliance of Genome Resources, Apr 2022]

ZFYVE28 Products (6)

mRNA Protein Name
NM_001172656.2 NP_001166127.1 lateral signaling target protein 2 homolog isoform 3
NM_001172657.2 NP_001166128.1 lateral signaling target protein 2 homolog isoform 4
NM_001172658.3 NP_001166129.1 lateral signaling target protein 2 homolog isoform 5
NM_001172659.2 NP_001166130.1 lateral signaling target protein 2 homolog isoform 1
NM_001172660.3 NP_001166131.1 lateral signaling target protein 2 homolog isoform 6
NM_020972.3 NP_066023.2 lateral signaling target protein 2 homolog isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables phosphatidylinositol-3-phosphate binding IDA
IDA: Inferred from direct assay
19460345 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
19460345 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of epidermal growth factor receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
19460345 GOA
involved in negative regulation of epidermal growth factor-activated receptor activity IMP
IMP: Inferred from mutant phenotype
19460345 GOA
Cellular Component GO Annotation Evidence References Source
located in cytosol IDA
IDA: Inferred from direct assay
19460345 GOA
located in early endosome membrane IDA
IDA: Inferred from direct assay
19460345 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZFYVE28 Protein Structure

FYVE

FYVE: FYVE zinc finger (813 - 873)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 887 a.a.
Protein Preferred Names Protein Names

lateral signaling target protein 2 homolog

  • hLst2

Related Diseases

Diseases Alias
Adiaspiromycosis
Anti-Basement Membrane Glomerulonephritis

  • Anti-Gbm Glomerulonephritis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS16061 ZFYVE28 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus ZFYVE28 MGD MGI:2684992
Macaca mulatta ZFYVE28 VGNC VGNC:107211
Bos taurus ZFYVE28 VGNC VGNC:37178
Canis familiaris ZFYVE28 VGNC VGNC:53255
Felis catus ZFYVE28 VGNC VGNC:107480
Rattus norvegicus ZFYVE28 RGD RGD:1310151
Others ZFYVE28 NCBI