Trdn - triadin Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 59299

Summary

Predicted to enable protein-macromolecule adaptor activity and transmembrane transporter binding activity. Involved in several processes, including cytoplasmic microtubule organization; endoplasmic reticulum membrane organization; and regulation of release of sequestered calcium ion into cytosol. Located in junctional sarcoplasmic reticulum membrane and plasma membrane. Part of Calcium Channel complex and junctional membrane complex. Human ortholog(s) of this gene implicated in catecholaminergic polymorphic ventricular tachycardia and catecholaminergic polymorphic ventricular tachycardia 5. Orthologous to human TRDN (triadin). [provided by Alliance of Genome Resources, Apr 2022]

Trdn Products (1)

mRNA Protein Name
NM_021666.4 NP_067698.2 triadin

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
16176928 RGD
Biological Process GO Annotation Evidence References Source
involved in cytoplasmic microtubule organization IMP
IMP: Inferred from mutant phenotype
22505613 RGD
involved in endoplasmic reticulum membrane organization IMP
IMP: Inferred from mutant phenotype
22505613 RGD
involved in intracellular calcium ion homeostasis IMP
IMP: Inferred from mutant phenotype
18845610 RGD
involved in myotube differentiation IEP
IEP: Inferred from expression pattern
10713145 RGD
involved in negative regulation of release of sequestered calcium ion into cytosol IMP
IMP: Inferred from mutant phenotype
16176928 RGD
involved in positive regulation of release of sequestered calcium ion into cytosol IMP
IMP: Inferred from mutant phenotype
21811790 RGD
involved in regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum IMP
IMP: Inferred from mutant phenotype
17569730 RGD
involved in response to organic cyclic compound IEP
IEP: Inferred from expression pattern
18602130 RGD
Cellular Component GO Annotation Evidence References Source
part of calcium channel complex IGI
IGI: Inferred from genetic interaction
22422768 RGD
part of junctional membrane complex IDA
IDA: Inferred from direct assay
22505613 RGD
part of junctional membrane complex IMP
IMP: Inferred from mutant phenotype
22505613 RGD
located in junctional sarcoplasmic reticulum membrane IDA
IDA: Inferred from direct assay
7565919 RGD
located in plasma membrane IDA
IDA: Inferred from direct assay
22422768 RGD
located in sarcoplasmic reticulum IDA
IDA: Inferred from direct assay
21811790 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

triadin

  • triadin 1

  • triadin 32 kDa (TRISK 32)

  • triadin 49 kDa (TRISK 49)

  • triadin 95

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15000 TRDN Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21448 Trdn Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27966 Trdn Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Trdn NCBI NCBI:10345