HIF3A - hypoxia inducible factor 3 subunit alpha Gene

Also Known as IPAS; MOP7; PASD7; HIF-3A; bHLHe17; HIF3-alpha-1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 64344

About HIF3A

Cytogenetic location: 19q13.32 Genomic coordinates (GRCh38): 19:46,297,042-46,343,433 (from NCBI)

This gene has 19 transcripts (splice variants), 191 orthologues and 7 paralogues. Broad expression in placenta (RPKM 8.3), spleen (RPKM 6.6) and 17 other tissues.

Summary

The protein encoded by this gene is the alpha-3 subunit of one of several alpha/beta-subunit heterodimeric transcription factors that regulate many adaptive responses to low oxygen tension (hypoxia). The alpha-3 subunit lacks the transactivation domain found in factors containing either the alpha-1 or alpha-2 subunits. It is thought that factors containing the alpha-3 subunit are negative regulators of hypoxia-inducible gene expression. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2011]

HIF3A Products (4)

mRNA Protein Name
NM_022462.4 NP_071907.4 hypoxia-inducible factor 3-alpha isoform b
NM_152794.4 NP_690007.1 hypoxia-inducible factor 3-alpha isoform a
NM_152795.4 NP_690008.2 hypoxia-inducible factor 3-alpha isoform c
NM_152796.2 NP_690009.1 hypoxia-inducible factor 3-alpha isoform d

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription factor activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
11573933 GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
31768607 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16126907 GOA
Biological Process GO Annotation Evidence References Source
NOT involved in cellular response to hypoxia IDA
IDA: Inferred from direct assay
11573933 GOA
involved in regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
11573933 GOA
Cellular Component GO Annotation Evidence References Source
located in chromatin IDA
IDA: Inferred from direct assay
31768607 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HIF3A Protein Structure

PAS

PAS: PAS fold (92 - 146)

PAS_11

PAS_11: PAS domain (241 - 343)

HIF-1

HIF-1: Hypoxia-inducible factor-1 (478 - 509)

  • 0
  • 200
  • 400
  • 600
  • 669 a.a.
Protein Preferred Names Protein Names

hypoxia-inducible factor 3-alpha

  • PAS domain-containing protein 7

Related Diseases

Diseases Alias
Erythrocytosis, Familial, 4

  • ECYT4

  • Familial Erythrocytosis 4

  • Erythrocytosis, Familial, Type 4
Erythrocytosis, Familial, 3

  • ECYT3

  • Familial Erythrocytosis 3

  • Erythrocytosis, Familial, Type 3
Erythrocytosis, Familial, 8

  • Diphosphoglycerate Mutase Deficiency Of Erythrocyte

  • ECYT8

  • Bisphosphoglycerate Mutase Deficiency

  • Bisphosphoglyceromutase Deficiency

  • Bpgm Deficiency

  • Dpgm Deficiency

  • Deficiency Of Bisphosphoglycerate Mutase

  • Familial Erythrocytosis 8

  • Hemolytic Anemia Due To Diphosphoglycerate Mutase Deficiency

  • Erythrocytosis Due To Bisphosphoglycerate Mutase Deficiency

  • Erythrocytosis, Familial, Type 8
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06170 HIF3A Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus HIF3A VGNC VGNC:62814
Macaca mulatta HIF3A VGNC VGNC:73395
Mus musculus HIF3A MGD MGI:1859778
Rattus norvegicus HIF3A RGD RGD:70332
Bos taurus HIF3A VGNC VGNC:29850
Others HIF3A NCBI