2. Gene
  3. Nrgn - neurogranin Gene

Nrgn - neurogranin Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as RC3; BICKS

Gene ID: 64356 | Gene type: protein coding

About Nrgn

Summary

Enables Calmodulin binding activity; phosphatidic acid binding activity; and phosphatidylinositol-3,4,5-trisphosphate binding activity. Involved in associative learning; modulation of chemical synaptic transmission; and telencephalon development. Located in several cellular components, including dendritic spine head; postsynaptic density; and trans-Golgi network transport vesicle membrane. Is active in glutamatergic synapse and postsynaptic membrane. Biomarker of hypothyroidism and visual epilepsy. Orthologous to human NRGN (neurogranin). [provided by Alliance of Genome Resources, Apr 2022]

Nrgn Products(1)

mRNA Protein Name
NM_024140.3 NP_077054.1 neurogranin
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables calmodulin binding IDA
IDA: Inferred from direct assay
8080473 RGD
enables phosphatidic acid binding IDA
IDA: Inferred from direct assay
17295609 RGD
enables phosphatidylinositol-3,4,5-trisphosphate binding IDA
IDA: Inferred from direct assay
8995284 RGD
Biological Process GO Annotation Evidence Reference Source
involved in associative learning IEP
IEP: Inferred from expression pattern
12223542 RGD
involved in positive regulation of long-term synaptic potentiation IMP
IMP: Inferred from mutant phenotype
7620629 RGD
involved in postsynaptic modulation of chemical synaptic transmission IDA
IDA: Inferred from direct assay
19713936 RGD
involved in postsynaptic modulation of chemical synaptic transmission IMP
IMP: Inferred from mutant phenotype
19713936 RGD
involved in telencephalon development IEP
IEP: Inferred from expression pattern
8783271 RGD
Cellular Component GO Annotation Evidence Reference Source
located in axon IDA
IDA: Inferred from direct assay
10700012 RGD
located in dendrite IDA
IDA: Inferred from direct assay
10700012 RGD
located in dendritic spine head IDA
IDA: Inferred from direct assay
8891262 RGD
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
1528865 RGD
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
19713936 RGD
located in mitochondrial membrane IDA
IDA: Inferred from direct assay
8891262 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
8783271 RGD
is active in postsynapse IDA
IDA: Inferred from direct assay
1528865 RGD
is active in postsynaptic membrane IDA
IDA: Inferred from direct assay
19713936 RGD
located in trans-Golgi network transport vesicle membrane IDA
IDA: Inferred from direct assay
8891262 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

neurogranin

neurogranin (protein kinase C substrate, RC3)

ng

protein kinase C substrate 7.5 kDa protein

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS09570 NRGN Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Nrgn NCBI NCBI:4900