Eif2b1 - eukaryotic translation initiation factor 2B subunit alpha Gene

Also Known as eIF-2a

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 64514

Summary

Enables GDP binding activity; GTP binding activity; and translation initiation factor activity. Contributes to guanyl-nucleotide exchange factor activity. Involved in several processes, including negative regulation of guanyl-nucleotide exchange factor activity; response to amino acid starvation; and translational initiation. Part of eukaryotic translation initiation factor 2 complex and eukaryotic translation initiation factor 2B complex. Human ortholog(s) of this gene implicated in leukoencephalopathy with vanishing white matter. Orthologous to human EIF2B1 (eukaryotic translation initiation factor 2B subunit alpha). [provided by Alliance of Genome Resources, Apr 2022]

Eif2b1 Products (1)

mRNA Protein Name
NM_172029.2 NP_742026.1 translation initiation factor eIF-2B subunit alpha

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables GDP binding IDA
IDA: Inferred from direct assay
3818593 RGD
enables GTP binding IMP
IMP: Inferred from mutant phenotype
3818593 RGD
contributes to guanyl-nucleotide exchange factor activity IDA
IDA: Inferred from direct assay
9631509 RGD
enables translation initiation factor activity IDA
IDA: Inferred from direct assay
3818593 RGD
Biological Process GO Annotation Evidence References Source
involved in negative regulation of guanyl-nucleotide exchange factor activity IDA
IDA: Inferred from direct assay
9582312 RGD
involved in response to amino acid starvation IDA
IDA: Inferred from direct assay
11500297 RGD
involved in response to glucose IDA
IDA: Inferred from direct assay
8567668 RGD
involved in response to heat IDA
IDA: Inferred from direct assay
9341116 RGD
involved in response to peptide hormone IDA
IDA: Inferred from direct assay
8430778 RGD
involved in translation IDA
IDA: Inferred from direct assay
3818593 RGD
involved in translational initiation IDA
IDA: Inferred from direct assay
3818593 RGD
Cellular Component GO Annotation Evidence References Source
part of eukaryotic translation initiation factor 2 complex IDA
IDA: Inferred from direct assay
3818593 RGD
part of eukaryotic translation initiation factor 2B complex IDA
IDA: Inferred from direct assay
9631509 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

translation initiation factor eIF-2B subunit alpha

  • GTP-exchange protein

  • eIF-2B GDP-GTP exchange factor subunit alpha

  • eIF-2Balpha

  • eukaryotic translation initiation factor 2B subunit 1 alpha

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04248 EIF2B1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Eif2b1 NCBI NCBI:1967