Eif2b1 - eukaryotic translation initiation factor 2B subunit alpha Gene

Rattus norvegicus

Also known as eIF-2a

Gene ID: 64514 | Gene type: protein coding

About Eif2b1

Summary

Enables GDP binding activity; GTP binding activity; and translation initiation factor activity. Contributes to guanyl-nucleotide exchange factor activity. Involved in several processes, including negative regulation of guanyl-nucleotide exchange factor activity; response to amino acid starvation; and translational initiation. Part of eukaryotic translation initiation factor 2 complex and eukaryotic translation initiation factor 2B complex. Human ortholog(s) of this gene implicated in leukoencephalopathy with vanishing white matter. Orthologous to human EIF2B1 (eukaryotic translation initiation factor 2B subunit alpha). [provided by Alliance of Genome Resources, Apr 2022]

Eif2b1 Products(1)

mRNA	Protein	Name
NM_172029.2	NP_742026.1	translation initiation factor eIF-2B subunit alpha

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables GDP binding	IDA IDA: Inferred from direct assay	3818593	RGD
enables GTP binding	IMP IMP: Inferred from mutant phenotype	3818593	RGD
contributes to guanyl-nucleotide exchange factor activity	IDA IDA: Inferred from direct assay	9631509	RGD
enables translation initiation factor activity	IDA IDA: Inferred from direct assay	3818593	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of guanyl-nucleotide exchange factor activity	IDA IDA: Inferred from direct assay	9582312	RGD
involved in response to amino acid starvation	IDA IDA: Inferred from direct assay	11500297	RGD
involved in response to glucose	IDA IDA: Inferred from direct assay	8567668	RGD
involved in response to heat	IDA IDA: Inferred from direct assay	9341116	RGD
involved in response to peptide hormone	IDA IDA: Inferred from direct assay	8430778	RGD
involved in translation	IDA IDA: Inferred from direct assay	3818593	RGD
involved in translational initiation	IDA IDA: Inferred from direct assay	3818593	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
part of eukaryotic translation initiation factor 2 complex	IDA IDA: Inferred from direct assay	3818593	RGD
part of eukaryotic translation initiation factor 2B complex	IDA IDA: Inferred from direct assay	9631509	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

translation initiation factor eIF-2B subunit alpha

GTP-exchange protein	eIF-2B GDP-GTP exchange factor subunit alpha
eIF-2Balpha	eukaryotic translation initiation factor 2B subunit 1 alpha

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04248	EIF2B1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Eif2b1	NCBI	NCBI:1967

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