2. Gene
  3. Nisch - nischarin Gene

Nisch - nischarin Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as I-1; edsn; 1200007D05Rik; 3202002H23Rik

Gene ID: 64652 | Gene type: protein coding

About Nisch

Summary

Enables Integrin binding activity. Acts upstream of or within Rac protein signal transduction; actin Cytoskeleton organization; and negative regulation of cell migration. Located in cytosol. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and integumental system. Used to study otitis media. Human ortholog(s) of this gene implicated in congestive heart failure. Orthologous to human NISCH (nischarin). [provided by Alliance of Genome Resources, Apr 2022]

Nisch Products(2)

mRNA Protein Name
NM_001347583.1 NP_001334512.1 nischarin isoform 2
NM_022656.2 NP_073147.2 nischarin isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables integrin binding IDA
IDA: Inferred from direct assay
11121431 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within Rac protein signal transduction IDA
IDA: Inferred from direct assay
11121431 MGI
acts upstream of or within actin cytoskeleton organization IDA
IDA: Inferred from direct assay
11121431 MGI
acts upstream of or within negative regulation of cell migration IDA
IDA: Inferred from direct assay
11121431 MGI
Cellular Component GO Annotation Evidence Reference Source
located in cytosol IDA
IDA: Inferred from direct assay
11121431 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

nischarin

I1R

IR1

imidazoline receptor 1

imidazoline receptor I-1-like protein

imidazoline-1 receptor

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS09309 NISCH Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Nisch NCBI NCBI:11188