Nisch - nischarin Gene

Also Known as I-1; edsn; 1200007D05Rik; 3202002H23Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 64652

Summary

Enables Integrin binding activity. Acts upstream of or within Rac protein signal transduction; actin Cytoskeleton organization; and negative regulation of cell migration. Located in cytosol. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and integumental system. Used to study otitis media. Human ortholog(s) of this gene implicated in congestive heart failure. Orthologous to human NISCH (nischarin). [provided by Alliance of Genome Resources, Apr 2022]

Nisch Products (2)

mRNA Protein Name
NM_001347583.1 NP_001334512.1 nischarin isoform 2
NM_022656.2 NP_073147.2 nischarin isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables integrin binding IDA
IDA: Inferred from direct assay
11121431 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within Rac protein signal transduction IDA
IDA: Inferred from direct assay
11121431 MGI
acts upstream of or within actin cytoskeleton organization IDA
IDA: Inferred from direct assay
11121431 MGI
acts upstream of or within negative regulation of cell migration IDA
IDA: Inferred from direct assay
11121431 MGI
Cellular Component GO Annotation Evidence References Source
located in cytosol IDA
IDA: Inferred from direct assay
11121431 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

nischarin

  • I1R

  • IR1

  • imidazoline receptor 1

  • imidazoline receptor I-1-like protein

  • imidazoline-1 receptor

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09309 NISCH Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Nisch NCBI NCBI:11188