Srd5a2 - steroid 5 alpha-reductase 2 Gene

Rattus norvegicus

Also known as S5AR 2

Gene ID: 64677 | Gene type: protein coding

About Srd5a2

Summary

Enables 3-oxo-5-alpha-steroid 4-dehydrogenase activity and amide binding activity. Involved in several processes, including androgen biosynthetic process; animal organ development; and phthalate metabolic process. Located in cell body fiber; cytoplasm; and neuronal cell body. Biomarker of diabetes mellitus and hyperprolactinemia. Human ortholog(s) of this gene implicated in hypospadias and prostate Cancer. Orthologous to human SRD5A2 (steroid 5 alpha-reductase 2). [provided by Alliance of Genome Resources, Apr 2022]

Srd5a2 Products(1)

mRNA	Protein	Name
NM_022711.5	NP_073202.1	3-oxo-5-alpha-steroid 4-dehydrogenase 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables 3-oxo-5-alpha-steroid 4-dehydrogenase activity	IDA IDA: Inferred from direct assay	1527072	RGD
enables amide binding	IPI IPI: Inferred from physical interaction	9328210	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in androgen biosynthetic process	IDA IDA: Inferred from direct assay	12606426	RGD
involved in androgen metabolic process	IDA IDA: Inferred from direct assay	20954080	RGD
involved in biphenyl metabolic process	IEP IEP: Inferred from expression pattern	16938428	RGD
involved in bone development	IEP IEP: Inferred from expression pattern	15012600	RGD
involved in dibenzo-p-dioxin metabolic process	IEP IEP: Inferred from expression pattern	11222880	RGD
involved in female genitalia development	IEP IEP: Inferred from expression pattern	9142501	RGD
involved in hippocampus development	IEP IEP: Inferred from expression pattern	21047951	RGD
involved in hypothalamus development	IEP IEP: Inferred from expression pattern	15804399	RGD
involved in male genitalia development	IEP IEP: Inferred from expression pattern	9142501	RGD
involved in male gonad development	IEP IEP: Inferred from expression pattern	12606426	RGD
involved in phthalate metabolic process	IEP IEP: Inferred from expression pattern	20954080	RGD
involved in response to biphenyl	IDA IDA: Inferred from direct assay	12443045	RGD
involved in response to follicle-stimulating hormone	IEP IEP: Inferred from expression pattern	12630924	RGD
involved in response to nutrient levels	IEP IEP: Inferred from expression pattern	16425201	RGD
involved in response to organic cyclic compound	IEP IEP: Inferred from expression pattern	17940878	RGD
involved in response to peptide hormone	IDA IDA: Inferred from direct assay	12630924	RGD
involved in response to steroid hormone	IEP IEP: Inferred from expression pattern	16076027	RGD
involved in response to testosterone	IEP IEP: Inferred from expression pattern	16595696	RGD
involved in response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	18978642	RGD
involved in steroid biosynthetic process	IDA IDA: Inferred from direct assay	1527072	RGD
involved in steroid catabolic process	IDA IDA: Inferred from direct assay	1527072	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in cell body fiber	IDA IDA: Inferred from direct assay	15305365	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	15305365	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

3-oxo-5-alpha-steroid 4-dehydrogenase 2

5 alpha-SR2	SR type 2
steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2)

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13755	SRD5A2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21944	Srd5a2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Srd5a2	NCBI	NCBI:6716

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