Srd5a2 - steroid 5 alpha-reductase 2 Gene

Also Known as S5AR 2

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 64677

Summary

Enables 3-oxo-5-alpha-steroid 4-dehydrogenase activity and amide binding activity. Involved in several processes, including androgen biosynthetic process; animal organ development; and phthalate metabolic process. Located in cell body fiber; cytoplasm; and neuronal cell body. Biomarker of diabetes mellitus and hyperprolactinemia. Human ortholog(s) of this gene implicated in hypospadias and prostate Cancer. Orthologous to human SRD5A2 (steroid 5 alpha-reductase 2). [provided by Alliance of Genome Resources, Apr 2022]

Srd5a2 Products (1)

mRNA Protein Name
NM_022711.5 NP_073202.1 3-oxo-5-alpha-steroid 4-dehydrogenase 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables 3-oxo-5-alpha-steroid 4-dehydrogenase activity IDA
IDA: Inferred from direct assay
1527072 RGD
enables amide binding IPI
IPI: Inferred from physical interaction
9328210 RGD
Biological Process GO Annotation Evidence References Source
involved in androgen biosynthetic process IDA
IDA: Inferred from direct assay
12606426 RGD
involved in androgen metabolic process IDA
IDA: Inferred from direct assay
20954080 RGD
involved in biphenyl metabolic process IEP
IEP: Inferred from expression pattern
16938428 RGD
involved in bone development IEP
IEP: Inferred from expression pattern
15012600 RGD
involved in dibenzo-p-dioxin metabolic process IEP
IEP: Inferred from expression pattern
11222880 RGD
involved in female genitalia development IEP
IEP: Inferred from expression pattern
9142501 RGD
involved in hippocampus development IEP
IEP: Inferred from expression pattern
21047951 RGD
involved in hypothalamus development IEP
IEP: Inferred from expression pattern
15804399 RGD
involved in male genitalia development IEP
IEP: Inferred from expression pattern
9142501 RGD
involved in male gonad development IEP
IEP: Inferred from expression pattern
12606426 RGD
involved in phthalate metabolic process IEP
IEP: Inferred from expression pattern
20954080 RGD
involved in response to biphenyl IDA
IDA: Inferred from direct assay
12443045 RGD
involved in response to follicle-stimulating hormone IEP
IEP: Inferred from expression pattern
12630924 RGD
involved in response to nutrient levels IEP
IEP: Inferred from expression pattern
16425201 RGD
involved in response to organic cyclic compound IEP
IEP: Inferred from expression pattern
17940878 RGD
involved in response to peptide hormone IDA
IDA: Inferred from direct assay
12630924 RGD
involved in response to steroid hormone IEP
IEP: Inferred from expression pattern
16076027 RGD
involved in response to testosterone IEP
IEP: Inferred from expression pattern
16595696 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
18978642 RGD
involved in steroid biosynthetic process IDA
IDA: Inferred from direct assay
1527072 RGD
involved in steroid catabolic process IDA
IDA: Inferred from direct assay
1527072 RGD
Cellular Component GO Annotation Evidence References Source
located in cell body fiber IDA
IDA: Inferred from direct assay
15305365 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
15305365 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

3-oxo-5-alpha-steroid 4-dehydrogenase 2

  • 5 alpha-SR2

  • SR type 2

  • steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2)

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13755 SRD5A2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21944 Srd5a2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Srd5a2 NCBI NCBI:6716