2. Gene
  3. CYP3A43 - cytochrome P450 family 3 subfamily A member 43 Gene

CYP3A43 - cytochrome P450 family 3 subfamily A member 43 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens
Gene ID: 64816 | Gene type: protein coding

About CYP3A43

Cytogenetic location: 7q22.1 Genomic coordinates (GRCh38): 7:99,828,013-99,866,093 (from NCBI)

This gene has 16 transcripts (splice variants), 677 orthologues and 3 paralogues. Biased expression in liver (RPKM 2.4), testis (RPKM 0.3) and 1 other tissue.

Summary

This gene encodes a member of the Cytochrome P450 superfamily of enzymes. The Cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of Cholesterol, Steroids and other lipids. The encoded protein has a low level of testosterone hydroxylase activity, and may play a role in aging mechanisms and Cancer progression. This gene is part of a cluster of Cytochrome P450 genes on chromosome 7q21.1. Alternate splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2013]

CYP3A43 Products(4)

mRNA Protein Name
NM_001278921.2 NP_001265850.1 cytochrome P450 3A43 isoform 4
NM_022820.5 NP_073731.1 cytochrome P450 3A43 isoform 1
NM_057095.3 NP_476436.1 cytochrome P450 3A43 isoform 2
NM_057096.4 NP_476437.1 cytochrome P450 3A43 isoform 3

CYP3A43 Protein Structure

p450

p450: Cytochrome P450 (39 - 493)

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  • 503 a.a.
Protein Preferred Names Protein Names

cytochrome P450 3A43

cytochrome P450, family 3, subfamily A, polypeptide 43

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS03472 CYP3A43 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta CYP3A43 VGNC VGNC:103656
Rattus norvegicus CYP3A43 RGD RGD:628709