Unc13b - unc-13 homolog B Gene

Also Known as Unc13h2; Munc13-2

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 64830

Summary

Enables Calmodulin binding activity and syntaxin-1 binding activity. Involved in several processes, including positive regulation of inhibitory postsynaptic potential; positive regulation of secretion by cell; and secretion by cell. Located in cytosol; synaptic membrane; and terminal bouton. Orthologous to human UNC13B (unc-13 homolog B). [provided by Alliance of Genome Resources, Apr 2022]

Unc13b Products (2)

mRNA	Protein	Name
NM_001042579.2	NP_001036044.2	protein unc-13 homolog B isoform u
NM_022862.3	NP_074053.2	protein unc-13 homolog B isoform b

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables calmodulin binding	IDA IDA: Inferred from direct assay	19492809	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	11343654	RGD
enables syntaxin binding	IDA IDA: Inferred from direct assay	9895278	RGD
enables syntaxin-1 binding	IDA IDA: Inferred from direct assay	9895278	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in cellular response to glucose stimulus	IMP IMP: Inferred from mutant phenotype	19641095	RGD
involved in dense core granule priming	IGI IGI: Inferred from genetic interaction	26575293	RGD
involved in positive regulation of exocytosis	IMP IMP: Inferred from mutant phenotype	24356451	RGD
involved in positive regulation of inhibitory postsynaptic potential	IGI IGI: Inferred from genetic interaction	21262469	RGD
involved in positive regulation of protein secretion	IMP IMP: Inferred from mutant phenotype	19641095	RGD
involved in positive regulation of synaptic vesicle priming	IGI IGI: Inferred from genetic interaction	21262469	RGD
involved in regulation of presynaptic dense core granule exocytosis	IDA IDA: Inferred from direct assay	31679900	RGD
involved in regulation of presynaptic dense core granule exocytosis	IEP IEP: Inferred from expression pattern	31679900	RGD
involved in regulation of presynaptic dense core granule exocytosis	IMP IMP: Inferred from mutant phenotype	31679900	RGD
involved in spontaneous neurotransmitter secretion	IGI IGI: Inferred from genetic interaction	21262469	RGD
involved in synaptic vesicle priming	IMP IMP: Inferred from mutant phenotype	22966208	RGD

Cellular Component GO Annotation	Evidence	References	Source
located in cytosol	IDA IDA: Inferred from direct assay	9895278	RGD
located in plasma membrane	IGI IGI: Inferred from genetic interaction	21262469	RGD
located in synaptic membrane	IDA IDA: Inferred from direct assay	9895278	RGD
located in terminal bouton	IGI IGI: Inferred from genetic interaction	21262469	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
protein unc-13 homolog B

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15465	UNC13B Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Unc13b	NCBI	NCBI:10497