2. Gene
  3. Chd8 - chromodomain helicase DNA binding protein 8 Gene

Chd8 - chromodomain helicase DNA binding protein 8 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as CHD-8

Gene ID: 65027 | Gene type: protein coding

About Chd8

Summary

This gene encodes a member of the chromodomain-helicase-DNA binding protein family, which is characterized by a SNF2-like domain and two chromatin organization modifier domains. The encoded protein also contains brahma and kismet domains, which is common to the subfamily of chromodomain-helicase-DNA binding proteins to which this protein belongs. In mammals, this gene has been shown to function in several processes including transcriptional regulation, epigenetic remodeling, promotion of cell proliferation, and regulation of RNA synthesis. Knockout of this gene in mice causes early embryonic lethality due to widespread Apoptosis. Heterozygous loss of function mutations in mice result in autism spectrum disorder-like behaviors that include increased anxiety, repetitive behavior, and altered social behavior. [provided by RefSeq, Dec 2016]

Chd8 Products(1)

mRNA Protein Name
NM_001347661.1 NP_001334590.1 chromodomain-helicase-DNA-binding protein 8
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables armadillo repeat domain binding IPI
IPI: Inferred from physical interaction
10921920 RGD
enables beta-catenin binding IDA
IDA: Inferred from direct assay
10921920 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
11744694 RGD
Biological Process GO Annotation Evidence Reference Source
involved in negative regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
10921920 RGD
involved in negative regulation of Wnt signaling pathway IDA
IDA: Inferred from direct assay
10921920 RGD
involved in negative regulation of canonical Wnt signaling pathway IDA
IDA: Inferred from direct assay
10921920 RGD
Cellular Component GO Annotation Evidence Reference Source
located in nucleus IDA
IDA: Inferred from direct assay
10921920 RGD
part of protein-containing complex IDA
IDA: Inferred from direct assay
11744694 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

chromodomain-helicase-DNA-binding protein 8

ATP-dependent helicase CHD8

axis duplication inhibitor

beta-catenin binding protein

duplin

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS02613 CHD8 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Chd8 NCBI NCBI:57680