Inppl1 - inositol polyphosphate phosphatase-like 1 Gene

Also Known as Ship2

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 65038

Summary

Enables inositol-polyphosphate 5-phosphatase activity and phosphatidylinositol-3,4,5-trisphosphate binding activity. Involved in several processes, including inositol trisphosphate metabolic process; negative regulation of DNA replication; and negative regulation of signal transduction. Located in lamellipodium. Human ortholog(s) of this gene implicated in hypertension; obesity; and type 2 diabetes mellitus. Orthologous to human INPPL1 (inositol polyphosphate Phosphatase like 1). [provided by Alliance of Genome Resources, Apr 2022]

Inppl1 Products (2)

mRNA	Protein	Name
NM_001270843.1	NP_001257772.1	phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 isoform 2
NM_022944.2	NP_075233.1	phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables inositol-polyphosphate 5-phosphatase activity	IDA IDA: Inferred from direct assay	10381377	RGD
enables phosphatidylinositol-3,4,5-trisphosphate binding	IDA IDA: Inferred from direct assay	12933696	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	12933696	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in inositol trisphosphate metabolic process	IDA IDA: Inferred from direct assay	12933696	RGD
involved in negative regulation of DNA replication	IMP IMP: Inferred from mutant phenotype	12933696	RGD
involved in negative regulation of MAP kinase activity	IMP IMP: Inferred from mutant phenotype	12933696	RGD
involved in negative regulation of insulin receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	11692174	RGD
involved in negative regulation of insulin-like growth factor receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	12933696	RGD
involved in negative regulation of neuron projection development	IMP IMP: Inferred from mutant phenotype	17535963	RGD
involved in negative regulation of platelet-derived growth factor receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	12933696	RGD
involved in response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	16155101	RGD

Cellular Component GO Annotation	Evidence	References	Source
located in lamellipodium	IDA IDA: Inferred from direct assay	17535963	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2	INPPL-1 SH2 domain-containing inositol 5'-phosphatase 2 SH2 domain-containing inositol phosphatase 2 SH2-containing inositol phosphatase 2 SHIP-2 inositol polyphosphate phosphatase-like protein 1 protein 51C

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06834	INPPL1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Inppl1	NCBI	NCBI:3636