Ap2s1 - adaptor related protein complex 2 subunit sigma 1 Gene

Rattus norvegicus

Also known as Ap17

Gene ID: 65046 | Gene type: protein coding

About Ap2s1

Summary

Predicted to enable clathrin adaptor activity. Predicted to be involved in vesicle-mediated transport. Part of AP-2 adaptor complex. Human ortholog(s) of this gene implicated in familial hypocalciuric hypercalcemia 3. Orthologous to human AP2S1 (adaptor related protein complex 2 subunit sigma 1). [provided by Alliance of Genome Resources, Apr 2022]

Ap2s1 Products(1)

mRNA	Protein	Name
NM_022952.2	NP_075241.2	AP-2 complex subunit sigma

Gene Ontology

Biological Process
Cellular Component

Biological Process GO Annotation	Evidence	Reference	Source
involved in postsynaptic neurotransmitter receptor internalization	EXP EXP: Inferred from Experiment	17289840	RGD
involved in postsynaptic neurotransmitter receptor internalization	IDA IDA: Inferred from direct assay	17289840	RGD
involved in postsynaptic neurotransmitter receptor internalization	IMP IMP: Inferred from mutant phenotype	17289840	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
part of AP-2 adaptor complex	IDA IDA: Inferred from direct assay	2040623	RGD
is active in extrinsic component of presynaptic endocytic zone membrane	IDA IDA: Inferred from direct assay	8682861	RGD
is active in glutamatergic synapse	EXP EXP: Inferred from Experiment	17289840	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	17289840	RGD
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	17289840	RGD
is active in synaptic vesicle	EXP EXP: Inferred from Experiment	33376223	RGD
is active in synaptic vesicle	IDA IDA: Inferred from direct assay	33376223	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

AP-2 complex subunit sigma

adapter-related protein complex 2 sigma subunit	adapter-related protein complex 2 subunit sigma
adaptor protein complex AP-2 subunit sigma	adaptor-related protein complex 2 subunit sigma
adaptor-related protein complex 2, sigma 1 subunit	clathrin ass

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00788	AP2S1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ap2s1	NCBI	NCBI:1175

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