MARCKSL1 - MARCKS like 1 Gene

Also Known as F52; MLP; MRP; MLP1; MACMARCKS

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 65108

About MARCKSL1

Cytogenetic location: 1p35.1 Genomic coordinates (GRCh38): 1:32,333,839-32,336,233 (from NCBI)

This gene has 1 transcript (splice variant), 124 orthologues and 1 paralogue. Broad expression in ovary (RPKM 132.8), brain (RPKM 127.5) and 24 other tissues.

Summary

This gene encodes a member of the myristoylated alanine-rich C-kinase substrate (MARCKS) family. Members of this family play a role in cytoskeletal regulation, protein kinase C signaling and Calmodulin signaling. The encoded protein affects the formation of adherens junction. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene are located on the long arm of chromosomes 6 and 10. [provided by RefSeq, Jun 2012]

MARCKSL1 Products (1)

mRNA	Protein	Name
NM_023009.7	NP_075385.1	MARCKS-related protein

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	24863880	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MARCKSL1 Protein Structure

MARCKS

0
100
195 a.a.

Protein Preferred Names	Protein Names
MARCKS-related protein	MARCKS-like protein 1

Related Diseases

Diseases	Alias
Valproate Embryopathy	Fetal Valproate Syndrome Fetal Valproic Acid Syndrome Fvs Valproic Acid Embryopathy Fetal Valproate Spectrum Disorder Valproate Embryopathy, Susceptibility To Foetal Valproate Syndrome Foetal Valproic Acid Syndrome Susceptibility To Valproate Embryopathy Valproic Acid Antenatal Infection
Neural Tube Defects	Spina Bifida Neural Tube Defect NTD Neural Tube Defects, Susceptibility To Spinal Dysraphism Spina Bifida, Susceptibility To Rachischisis Cleft Spine Open Spine Hydrocele Spinalis Neural Tube Defect Nos Sb - [Spina Bifida] Spinal Hernia Nos Spinal Fissure Nos
Anencephaly	Aprosencephaly Anencephalus Congenital Absence Of Brain Absence Of A Large Part Of The Brain And The Skull Anencephalia Anencephalic Monster Brain Absence Brain Agenesis Brain Aplasia Absent Brain Anencephalic Congenital Absence Of Cerebrum Congenital Hemicrania Incomplete Anencephaly

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08146	MARCKSL1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	MARCKSL1	VGNC	VGNC:31245
Canis familiaris	MARCKSL1	VGNC	VGNC:43022
Rattus norvegicus	MARCKSL1	RGD	RGD:621197
Macaca mulatta	MARCKSL1	VGNC	VGNC:74723
Felis catus	MARCKSL1	VGNC	VGNC:107582
Mus musculus	MARCKSL1	MGD	MGI:97143
Others	MARCKSL1	NCBI