Nkx6-1 - NK6 homeobox 1 Gene

Rattus norvegicus

Also known as Nkx61; Nkx6a; Nkx6.1

Gene ID: 65193 | Gene type: protein coding

About Nkx6-1

Summary

Enables DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin binding activity. Involved in several processes, including positive regulation of Insulin secretion; type B pancreatic cell development; and type B pancreatic cell proliferation. Located in nucleus. Orthologous to human NKX6-1 (NK6 homeobox 1). [provided by Alliance of Genome Resources, Apr 2022]

Nkx6-1 Products(2)

mRNA	Protein	Name
NM_031737.2	NP_113925.1	homeobox protein Nkx-6.1
NM_031737.2	NP_113925.1	homeobox protein Nkx-6.1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	10567713	RGD
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	15883383	RGD
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	15883383	RGD
enables chromatin binding	IDA IDA: Inferred from direct assay	15883383	RGD
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	15883383	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to cytokine stimulus	IEP IEP: Inferred from expression pattern	16948396	RGD
involved in cellular response to peptide hormone stimulus	IEP IEP: Inferred from expression pattern	20304194	RGD
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	15883383	RGD
involved in neurogenesis	IMP IMP: Inferred from mutant phenotype	18687784	RGD
involved in positive regulation of insulin secretion	IMP IMP: Inferred from mutant phenotype	15883383	RGD
involved in response to nicotine	IEP IEP: Inferred from expression pattern	18687784	RGD
involved in response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	17192469	RGD
involved in transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	15883383	RGD
involved in type B pancreatic cell development	IEP IEP: Inferred from expression pattern	9603781	RGD
involved in type B pancreatic cell proliferation	IDA IDA: Inferred from direct assay	24706823	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

homeobox protein Nkx-6.1

NK homeobox, family 6, A	NK6 transcription factor homolog A
NK6 transcription factor related, locus 1	homeobox protein NK-6 homolog A

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09335	NKX6-1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Nkx6-1	NCBI	NCBI:4825

Name
Email *

	Sorry, but the email address you supplied was invalid.