Nkx6-1 - NK6 homeobox 1 Gene

Also Known as Nkx61; Nkx6a; Nkx6.1

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 65193

Summary

Enables DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin binding activity. Involved in several processes, including positive regulation of Insulin secretion; type B pancreatic cell development; and type B pancreatic cell proliferation. Located in nucleus. Orthologous to human NKX6-1 (NK6 homeobox 1). [provided by Alliance of Genome Resources, Apr 2022]

Nkx6-1 Products (2)

mRNA Protein Name
NM_031737.2 NP_113925.1 homeobox protein Nkx-6.1
NM_031737.2 NP_113925.1 homeobox protein Nkx-6.1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
10567713 RGD
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
15883383 RGD
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
15883383 RGD
enables chromatin binding IDA
IDA: Inferred from direct assay
15883383 RGD
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
15883383 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to cytokine stimulus IEP
IEP: Inferred from expression pattern
16948396 RGD
involved in cellular response to peptide hormone stimulus IEP
IEP: Inferred from expression pattern
20304194 RGD
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
15883383 RGD
involved in neurogenesis IMP
IMP: Inferred from mutant phenotype
18687784 RGD
involved in positive regulation of insulin secretion IMP
IMP: Inferred from mutant phenotype
15883383 RGD
involved in response to nicotine IEP
IEP: Inferred from expression pattern
18687784 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
17192469 RGD
involved in transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
15883383 RGD
involved in type B pancreatic cell development IEP
IEP: Inferred from expression pattern
9603781 RGD
involved in type B pancreatic cell proliferation IDA
IDA: Inferred from direct assay
24706823 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

homeobox protein Nkx-6.1

  • NK homeobox, family 6, A

  • NK6 transcription factor homolog A

  • NK6 transcription factor related, locus 1

  • homeobox protein NK-6 homolog A

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09335 NKX6-1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Nkx6-1 NCBI NCBI:4825