Cyp2j4 - cytochrome P450, family 2, subfamily j, polypeptide 4 Gene

Rattus norvegicus

Also known as CYP2J2; CYPIIJ4

Gene ID: 65210 | Gene type: protein coding

About Cyp2j4

Summary

Enables NADPH-hemoprotein reductase activity and arachidonic acid monooxygenase activity. Involved in several processes, including negative regulation of Collagen biosynthetic process; negative regulation of peroxisome proliferator activated receptor signaling pathway; and positive regulation of tumor necrosis factor production. Located in endoplasmic reticulum membrane. Used to study nephritis; pre-eclampsia; and ureteral obstruction. Biomarker of Bacterial pneumonia and renal hypertension. Human ortholog(s) of this gene implicated in hypertension; myocardial infarction; pulmonary hypertension; renal fibrosis; and renal hypertension. Orthologous to human CYP2J2 (Cytochrome P450 family 2 subfamily J member 2). [provided by Alliance of Genome Resources, Apr 2022]

Cyp2j4 Products(1)

mRNA	Protein	Name
NM_023025.2	NP_075414.2	cytochrome P450 2J4

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables NADPH-hemoprotein reductase activity	IDA IDA: Inferred from direct assay	9143331	RGD
enables arachidonate monooxygenase activity	IDA IDA: Inferred from direct assay	9143331	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in arachidonate metabolic process	IDA IDA: Inferred from direct assay	9143331	RGD
involved in female pregnancy	IEP IEP: Inferred from expression pattern	17138762	RGD
involved in negative regulation of collagen biosynthetic process	IMP IMP: Inferred from mutant phenotype	25840911	RGD
involved in negative regulation of peroxisome proliferator activated receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	25840911	RGD
involved in positive regulation of extracellular matrix organization	IMP IMP: Inferred from mutant phenotype	29656108	RGD
involved in positive regulation of gluconeogenesis	IMP IMP: Inferred from mutant phenotype	29656108	RGD
involved in positive regulation of tumor necrosis factor production	IMP IMP: Inferred from mutant phenotype	25840911	RGD
involved in response to organic cyclic compound	IEP IEP: Inferred from expression pattern	10497137	RGD
involved in retinoid metabolic process	IDA IDA: Inferred from direct assay	9606960	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in endoplasmic reticulum membrane	IDA IDA: Inferred from direct assay	9143331	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

cytochrome P450 2J4

cytochrome P450, family 2, subfamily j, polypeptide 4

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03465	CYP2J2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

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