Cyp2j4 - cytochrome P450, family 2, subfamily j, polypeptide 4 Gene

Also Known as CYP2J2; CYPIIJ4

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 65210

Summary

Enables NADPH-hemoprotein reductase activity and arachidonic acid monooxygenase activity. Involved in several processes, including negative regulation of Collagen biosynthetic process; negative regulation of peroxisome proliferator activated receptor signaling pathway; and positive regulation of tumor necrosis factor production. Located in endoplasmic reticulum membrane. Used to study nephritis; pre-eclampsia; and ureteral obstruction. Biomarker of Bacterial pneumonia and renal hypertension. Human ortholog(s) of this gene implicated in hypertension; myocardial infarction; pulmonary hypertension; renal fibrosis; and renal hypertension. Orthologous to human CYP2J2 (Cytochrome P450 family 2 subfamily J member 2). [provided by Alliance of Genome Resources, Apr 2022]

Cyp2j4 Products (1)

mRNA Protein Name
NM_023025.2 NP_075414.2 cytochrome P450 2J4

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables NADPH-hemoprotein reductase activity IDA
IDA: Inferred from direct assay
9143331 RGD
enables arachidonate monooxygenase activity IDA
IDA: Inferred from direct assay
9143331 RGD
Biological Process GO Annotation Evidence References Source
involved in arachidonate metabolic process IDA
IDA: Inferred from direct assay
9143331 RGD
involved in female pregnancy IEP
IEP: Inferred from expression pattern
17138762 RGD
involved in negative regulation of collagen biosynthetic process IMP
IMP: Inferred from mutant phenotype
25840911 RGD
involved in negative regulation of peroxisome proliferator activated receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
25840911 RGD
involved in positive regulation of extracellular matrix organization IMP
IMP: Inferred from mutant phenotype
29656108 RGD
involved in positive regulation of gluconeogenesis IMP
IMP: Inferred from mutant phenotype
29656108 RGD
involved in positive regulation of tumor necrosis factor production IMP
IMP: Inferred from mutant phenotype
25840911 RGD
involved in response to organic cyclic compound IEP
IEP: Inferred from expression pattern
10497137 RGD
involved in retinoid metabolic process IDA
IDA: Inferred from direct assay
9606960 RGD
Cellular Component GO Annotation Evidence References Source
located in endoplasmic reticulum membrane IDA
IDA: Inferred from direct assay
9143331 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

cytochrome P450 2J4

cytochrome P450, family 2, subfamily j, polypeptide 4

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03465 CYP2J2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown