SLC7A2 - solute carrier family 7 member 2 Gene

Homo sapiens

Also known as CAT2; ATRC2; HCAT2

Gene ID: 6542 | Gene type: protein coding

About SLC7A2

Cytogenetic location: 8p22 Genomic coordinates (GRCh38): 8:17,494,069-17,570,566 (from NCBI)

This gene has 6 transcripts (splice variants), 244 orthologues and 12 paralogues. Broad expression in liver (RPKM 59.2), thyroid (RPKM 35.6) and 15 other tissues.

Summary

The protein encoded by this gene is a cationic amino acid transporter and a member of the APC (amino acid-polyamine-organocation) family of transporters. The encoded membrane protein is responsible for the cellular uptake of arginine, lysine and ornithine. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

SLC7A2 Products(5)

mRNA	Protein	Name
NM_001008539.4	NP_001008539.3	cationic amino acid transporter 2 isoform 2
NM_001164771.2	NP_001158243.1	cationic amino acid transporter 2 isoform 3
NM_001370337.1	NP_001357266.1	cationic amino acid transporter 2 isoform 4
NM_001370338.1	NP_001357267.1	cationic amino acid transporter 2 isoform 2
NM_003046.6	NP_003037.4	cationic amino acid transporter 2 isoform 1

SLC7A2 Protein Structure

AA_permease_2

AA_permease_C

0
200
400
600
658 a.a.

Protein Preferred Names

Protein Names

cationic amino acid transporter 2

low affinity cationic amino acid transporter 2

Related Diseases

Diseases

Alias

Asthma

Chronic Obstructive Asthma	Asthma, Diminished Response To Antileukotriene Treatment In
Bronchial Hyperreactivity	Asthma, Susceptibility To
Asthma, Bronchial	Asthma, Protection Against
Asthma, Nocturnal, Susceptibility To	Nocturnal Asthma
Asthma-Related Traits	Asthma-Related Traits, Susceptibility To
Asthma, Nocturnal	Chronic Obstructive Asthma With Acute Exacerbation
Chronic Obstructive Asthma With Status Asthmaticus	Exercise Induced Asthma
Exercise-Induced Asthma	Bronchial Asthma
Asthma, Exercise-Induced	Idiosyncratic Asthma
Unspecified Asthma With Acute Exacerbation	Asthma, Unspecified, With Stated Status Asthmaticus
Status Asthmaticus Nos	Acute Severe Asthma
Acute Severe Bronchial Asthma	Status Asthma
Status Post Asthmaticus

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13328	SLC7A2 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	SLC7A2	RGD	RGD:68387
Canis familiaris	SLC7A2	VGNC	VGNC:46474
Mus musculus	SLC7A2	MGD	MGI:99828
Bos taurus	SLC7A2	VGNC	VGNC:34928
Macaca mulatta	SLC7A2	VGNC	VGNC:77629
Felis catus	SLC7A2	VGNC	VGNC:65425

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