SLC7A2 - solute carrier family 7 member 2 Gene

Also Known as CAT2; ATRC2; HCAT2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 6542

About SLC7A2

Cytogenetic location: 8p22 Genomic coordinates (GRCh38): 8:17,494,069-17,570,566 (from NCBI)

This gene has 6 transcripts (splice variants), 244 orthologues and 12 paralogues. Broad expression in liver (RPKM 59.2), thyroid (RPKM 35.6) and 15 other tissues.

Summary

The protein encoded by this gene is a cationic Amino acid Transporter and a member of the APC (amino acid-polyamine-organocation) family of transporters. The encoded membrane protein is responsible for the cellular uptake of arginine, lysine and ornithine. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

SLC7A2 Products (5)

mRNA Protein Name
NM_001008539.4 NP_001008539.3 cationic amino acid transporter 2 isoform 2
NM_001164771.2 NP_001158243.1 cationic amino acid transporter 2 isoform 3
NM_001370337.1 NP_001357266.1 cationic amino acid transporter 2 isoform 4
NM_001370338.1 NP_001357267.1 cationic amino acid transporter 2 isoform 2
NM_003046.6 NP_003037.4 cationic amino acid transporter 2 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables L-amino acid transmembrane transporter activity IDA
IDA: Inferred from direct assay
23864433 GOA
enables L-arginine transmembrane transporter activity IDA
IDA: Inferred from direct assay
9174363 GOA
enables amino acid transmembrane transporter activity IDA
IDA: Inferred from direct assay
28684763 GOA
Biological Process GO Annotation Evidence References Source
involved in L-alpha-amino acid transmembrane transport IDA
IDA: Inferred from direct assay
23864433 GOA
involved in L-amino acid transport IDA
IDA: Inferred from direct assay
28684763 GOA
involved in L-arginine import across plasma membrane IDA
IDA: Inferred from direct assay
23864433 GOA
involved in L-arginine transmembrane transport IDA
IDA: Inferred from direct assay
9174363 GOA
involved in amino acid import across plasma membrane IDA
IDA: Inferred from direct assay
23864433 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLC7A2 Protein Structure

AA_permease_2

AA_permease_2: Amino acid permease (34 - 436)

AA_permease_C

AA_permease_C: C-terminus of AA_permease (556 - 606)

  • 0
  • 200
  • 400
  • 600
  • 658 a.a.
Protein Preferred Names Protein Names

cationic amino acid transporter 2

  • low affinity cationic amino acid transporter 2

Related Diseases

Diseases Alias
Asthma

  • Chronic Obstructive Asthma

  • Asthma, Diminished Response To Antileukotriene Treatment In

  • Bronchial Hyperreactivity

  • Asthma, Susceptibility To

  • Asthma, Bronchial

  • Asthma, Protection Against

  • Asthma, Nocturnal, Susceptibility To

  • Nocturnal Asthma

  • Asthma-Related Traits

  • Asthma-Related Traits, Susceptibility To

  • Asthma, Nocturnal

  • Chronic Obstructive Asthma With Acute Exacerbation

  • Chronic Obstructive Asthma With Status Asthmaticus

  • Exercise Induced Asthma

  • Exercise-Induced Asthma

  • Bronchial Asthma

  • Asthma, Exercise-Induced

  • Idiosyncratic Asthma

  • Unspecified Asthma With Acute Exacerbation

  • Asthma, Unspecified, With Stated Status Asthmaticus

  • Status Asthmaticus Nos

  • Acute Severe Asthma

  • Acute Severe Bronchial Asthma

  • Status Asthma

  • Status Post Asthmaticus
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS21940 Slc7a2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS13328 SLC7A2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28457 Slc7a2 Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus SLC7A2 RGD RGD:68387
Canis familiaris SLC7A2 VGNC VGNC:46474
Mus musculus SLC7A2 MGD MGI:99828
Bos taurus SLC7A2 VGNC VGNC:34928
Macaca mulatta SLC7A2 VGNC VGNC:77629
Felis catus SLC7A2 VGNC VGNC:65425
Others SLC7A2 NCBI