SLC22A2 - solute carrier family 22 member 2 Gene

Homo sapiens

Also known as OCT2

Gene ID: 6582 | Gene type: protein coding

About SLC22A2

Cytogenetic location: 6q25.3 Genomic coordinates (GRCh38): 6:160,216,755-160,258,821 (from NCBI)

This gene has 6 transcripts (splice variants), 327 orthologues and 22 paralogues. Restricted expression toward kidney (RPKM 70.1).

Summary

Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. This gene is one of three similar cation transporter genes located in a cluster on chromosome 6. The encoded protein contains twelve putative transmembrane domains and is a plasma integral membrane protein. It is found primarily in the kidney, where it may mediate the first step in cation reabsorption. [provided by RefSeq, Jul 2008]

SLC22A2 Products(1)

mRNA	Protein	Name
NM_003058.4	NP_003049.2	solute carrier family 22 member 2

SLC22A2 Protein Structure

Sugar_tr

0
100
200
300
400
500
555 a.a.

Protein Preferred Names

Protein Names

solute carrier family 22 member 2

organic cation transporter 2

Related Diseases

Diseases

Alias

Carnitine Deficiency, Systemic Primary

Carnitine Uptake Defect	Renal Carnitine Transport Defect
Systemic Primary Carnitine Deficiency	CDSP
Systemic Carnitine Deficiency	Carnitine Transporter Deficiency
Cud	Primary Carnitine Deficiency
Carnitine Uptake Deficiency	Carnitine Deficiency, Systemic, Due To Defect In Renal Reabsorption Of Carnitine
Carnitine Deficiency, Primary	Systemic Primary Carnitine Deficiency Disease
Deficiency Of Plasma-Membrane Carnitine Transporter	Scd
Carnitine Transporter, Plasma-Membrane, Deficiency Of	Carnitine Transport Defect
Carnitine Plasma-Membrane Transporter Deficiency	Carnitine Transporter Defect
Spcd

Type 1 Diabetes Mellitus 8

Diabetes Mellitus, Insulin-Dependent, 8	Iddm8
Insulin-Dependent Diabetes Mellitus 8	T1D8
Insulin-Dependent Diabetes Mellitus-8

Cataract 37

CTRCT37	Cca5
Cataract, Congenital, Cerulean Type, 5	Cataract 37, Autosomal Dominant
Congenital Cataract Cerulean Type 5

Cholestasis

Obstruction Of Bile Duct	Bile Duct Obstruction
Bile Occlusion	Extrahepatic Biliary Obstruction
Extrahepatic Bile Duct Obstruction	Bile Stasis
Biliary Stasis	Obstructive Hyperbilirubinemia
Obstructed Jaundice	Bile Duct Obstructed
Bile Ductal Obstruction	Biliary Duct Obstruction
Obstructed Bile Ductal	Obstructed Biliary Duct
Obstructed Biliary Ductal	Jaundice Regurgitation
Obstructive Jaundice	Cholestatic Jaundice
Cholestatic Jaundice Syndrome

Fanconi-Like Syndrome

Fanconi Like Syndrome

Lymphoma, Hodgkin, Classic

Hodgkin Lymphoma	Hodgkin Disease
Hodgkin'S Lymphoma	Hodgkins Lymphoma
Classic Hodgkin Lymphoma	CHL
Hodgkin Lymphoma, Susceptibility To	Hl
Hodgkin'S Sarcoma	Stage I Subdiaphragmatic Hodgkin Lymphoma
Stage Ii Subdiaphragmatic Hodgkin Lymphoma	Lymphoma, Hodgkin'S
Classic Hodgkin Disease	Hodgkin'S Disease
Lymphoma, Hodgkin, Susceptibility To	Hodgkin'S Disease Of Intrapelvic Lymph Nodes
Hodgkin'S Disease Of Lymph Nodes Of Inguinal Region And/Or Lower Limb	Malignant Lymphogranuloma
Malignant Lymphogranulomatosis	Malignant Hodgkin Lymphoma
Classical Hodgkin Lymphoma, Type Not Specified

Cystoisosporiasis

Isosporiasis	Infection By Isospora Belli And Isospora Hominis
Isosporosis	Infection By Isospora Belli Or Isospora Hominis
Isospora Belli Or Hominis Infection	Coccidial Infestation
Coccidiosis	Coccidial Dysentery
Intestinal Coccidiosis Nos

Fanconi Syndrome

Infantile Nephropathic Cystinosis	Adult Fanconi Syndrome
Congenital Fanconi Syndrome	De Toni-Fanconi Syndrome
Fanconi-De Toni Syndrome	Lignac-Fanconi Syndrome
Fanconi Renotubular Syndrome	Primary Fanconi Renotubular Syndrome
De Toni-Debre-Fanconi Syndrome	Adult Fanconi Anemia
Detoni Fanconi Syndrome	Fanconi-De-Toni Syndrome
Primary Fanconi Syndrome	Detoni-Debre-Fanconi Syndrome
Primary Fanconi Renal Syndrome	Fanconi Anemia
Cystinosis, Infantile Nephropathic	Fanconi-Bickel Syndrome
Renal Fanconi Syndrome	Lowe-Bickel Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13072	SLC22A2 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	SLC22A2	MGD	MGI:1335072
Felis catus	SLC22A2	VGNC	VGNC:99773
Rattus norvegicus	SLC22A2	RGD	RGD:61936
Bos taurus	SLC22A2	VGNC	VGNC:53805
Canis familiaris	SLC22A2	VGNC	VGNC:53985
Macaca mulatta	SLC22A2	VGNC	VGNC:83465

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