2. Gene
  3. Cubn - cubilin (intrinsic factor-cobalamin receptor) Gene

Cubn - cubilin (intrinsic factor-cobalamin receptor) Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as D2Wsu88e

Gene ID: 65969 | Gene type: protein coding

About Cubn

Summary

Predicted to enable several functions, including cargo receptor activity; Hemoglobin binding activity; and protein homodimerization activity. Acts upstream of or within lipoprotein transport; receptor-mediated endocytosis; and response to bacterium. Located in several cellular components, including brush border; clathrin-coated pit; and cytoplasmic vesicle. Is expressed in several structures, including egg cylinder; embryo endoderm; midgut; and renal proximal tubule. Orthologous to human CUBN (cubilin). [provided by Alliance of Genome Resources, Apr 2022]

Cubn Products(1)

mRNA Protein Name
NM_001081084.2 NP_001074553.1 cubilin precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
11856751 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within establishment of localization in cell IDA
IDA: Inferred from direct assay
15616221 MGI
acts upstream of or within establishment of localization in cell IMP
IMP: Inferred from mutant phenotype
15616221 MGI
acts upstream of or within lipoprotein transport IDA
IDA: Inferred from direct assay
15616221 MGI
acts upstream of or within receptor-mediated endocytosis IMP
IMP: Inferred from mutant phenotype
15616221 MGI
acts upstream of or within response to bacterium IEP
IEP: Inferred from expression pattern
23012479 MGI
Cellular Component GO Annotation Evidence Reference Source
located in Golgi apparatus IDA
IDA: Inferred from direct assay
15616221 MGI
located in apical part of cell IDA
IDA: Inferred from direct assay
11856751 MGI
located in apical plasma membrane IDA
IDA: Inferred from direct assay
15616221 MGI
located in brush border IDA
IDA: Inferred from direct assay
12815097 MGI
located in clathrin-coated pit IDA
IDA: Inferred from direct assay
15616221 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
11856751 MGI
located in endocytic vesicle IDA
IDA: Inferred from direct assay
15616221 MGI
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
15616221 MGI
located in endosome IDA
IDA: Inferred from direct assay
10766831 MGI
is active in microvillus membrane IDA
IDA: Inferred from direct assay
14321840 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

cubilin

intrinsic factor-cobalamin receptor

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS03356 CUBN Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cubn NCBI NCBI:8029