Eef1e1 - eukaryotic translation elongation factor 1 epsilon 1 Gene

Also Known as AIMP3; 1110003A02Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 66143

Summary

Involved in negative regulation of cell population proliferation and positive regulation of apoptotic process. Acts upstream of or within cellular response to leukemia inhibitory factor; positive regulation of DNA damage response, signal transduction by p53 class mediator; and positive regulation of apoptotic signaling pathway. Located in cytoplasm and nucleus. Part of Aminoacyl-tRNA Synthetase multienzyme complex. Is expressed in several structures, including central nervous system and retina. Orthologous to human EEF1E1 (eukaryotic translation elongation factor 1 epsilon 1). [provided by Alliance of Genome Resources, Apr 2022]

Eef1e1 Products (1)

mRNA Protein Name
NM_025380.2 NP_079656.1 eukaryotic translation elongation factor 1 epsilon-1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
15680327 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within cellular response to leukemia inhibitory factor IEP
IEP: Inferred from expression pattern
20439489 MGI
involved in negative regulation of cell population proliferation IDA
IDA: Inferred from direct assay
15680327 MGI
acts upstream of or within positive regulation of DNA damage response, signal transduction by p53 class mediator IMP
IMP: Inferred from mutant phenotype
15680327 MGI
involved in positive regulation of DNA damage response, signal transduction by p53 class mediator IMP
IMP: Inferred from mutant phenotype
15680327 MGI
involved in positive regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
15680327 MGI
acts upstream of or within positive regulation of apoptotic signaling pathway IMP
IMP: Inferred from mutant phenotype
15680327 MGI
Cellular Component GO Annotation Evidence References Source
part of aminoacyl-tRNA synthetase multienzyme complex IDA
IDA: Inferred from direct assay
12060739 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
15680327 MGI
located in nucleus IDA
IDA: Inferred from direct assay
15680327 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

eukaryotic translation elongation factor 1 epsilon-1

  • elongation factor p18

  • multisynthase complex auxiliary component p18

  • multisynthetase complex auxiliary component p18

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04178 EEF1E1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Eef1e1 NCBI NCBI:9521