Eef1e1 - eukaryotic translation elongation factor 1 epsilon 1 Gene

Mus musculus

Also known as AIMP3; 1110003A02Rik

Gene ID: 66143 | Gene type: protein coding

About Eef1e1

Summary

Involved in negative regulation of cell population proliferation and positive regulation of apoptotic process. Acts upstream of or within cellular response to leukemia inhibitory factor; positive regulation of DNA damage response, signal transduction by p53 class mediator; and positive regulation of apoptotic signaling pathway. Located in cytoplasm and nucleus. Part of Aminoacyl-tRNA Synthetase multienzyme complex. Is expressed in several structures, including central nervous system and retina. Orthologous to human EEF1E1 (eukaryotic translation elongation factor 1 epsilon 1). [provided by Alliance of Genome Resources, Apr 2022]

Eef1e1 Products(1)

mRNA	Protein	Name
NM_025380.2	NP_079656.1	eukaryotic translation elongation factor 1 epsilon-1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	15680327	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within cellular response to leukemia inhibitory factor	IEP IEP: Inferred from expression pattern	20439489	MGI
involved in negative regulation of cell population proliferation	IDA IDA: Inferred from direct assay	15680327	MGI
acts upstream of or within positive regulation of DNA damage response, signal transduction by p53 class mediator	IMP IMP: Inferred from mutant phenotype	15680327	MGI
involved in positive regulation of DNA damage response, signal transduction by p53 class mediator	IMP IMP: Inferred from mutant phenotype	15680327	MGI
involved in positive regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	15680327	MGI
acts upstream of or within positive regulation of apoptotic signaling pathway	IMP IMP: Inferred from mutant phenotype	15680327	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
part of aminoacyl-tRNA synthetase multienzyme complex	IDA IDA: Inferred from direct assay	12060739	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	15680327	MGI
located in nucleus	IDA IDA: Inferred from direct assay	15680327	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

eukaryotic translation elongation factor 1 epsilon-1

elongation factor p18	multisynthase complex auxiliary component p18
multisynthetase complex auxiliary component p18

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04178	EEF1E1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Eef1e1	NCBI	NCBI:9521

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