Retreg1 - reticulophagy regulator 1 Gene

Also Known as Fam134b; Retreg1d; 1810015C04Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 66270

Summary

Involved in negative regulation of neuron apoptotic process and reticulophagy. Acts upstream of or within Mitophagy and white fat cell differentiation. Located in cis-Golgi network. Is expressed in several structures, including alimentary system; central nervous system; ganglia; metanephros; and reproductive system. Human ortholog(s) of this gene implicated in hereditary sensory and autonomic neuropathy type 2B. Orthologous to human RETREG1 (reticulophagy regulator 1). [provided by Alliance of Genome Resources, Apr 2022]

Retreg1 Products (6)

mRNA Protein Name
NM_001034851.2 NP_001030023.1 reticulophagy regulator 1 isoform 1
NM_001277315.1 NP_001264244.1 reticulophagy regulator 1 isoform 2
NM_001277316.1 NP_001264245.1 reticulophagy regulator 1 isoform 3
NM_001277317.1 NP_001264246.1 reticulophagy regulator 1 isoform 4
NM_001277318.1 NP_001264247.1 reticulophagy regulator 1 isoform 5
NM_025459.3 NP_079735.2 reticulophagy regulator 1 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables endoplasmic reticulum-autophagosome adaptor activity IMP
IMP: Inferred from mutant phenotype
34338405 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
34338405 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within autophagy IDA
IDA: Inferred from direct assay
31446166 MGI
acts upstream of or within collagen catabolic process IMP
IMP: Inferred from mutant phenotype
34338405 MGI
acts upstream of or within endoplasmic reticulum organization IMP
IMP: Inferred from mutant phenotype
34338405 MGI
acts upstream of or within mitophagy IDA
IDA: Inferred from direct assay
31446166 MGI
involved in negative regulation of neuron apoptotic process IMP
IMP: Inferred from mutant phenotype
26040720 MGI
acts upstream of or within reticulophagy IDA
IDA: Inferred from direct assay
34338405 MGI
acts upstream of or within reticulophagy IMP
IMP: Inferred from mutant phenotype
34338405 MGI
involved in reticulophagy IMP
IMP: Inferred from mutant phenotype
26040720 MGI
acts upstream of or within white fat cell differentiation IDA
IDA: Inferred from direct assay
31446166 MGI
Cellular Component GO Annotation Evidence References Source
located in cis-Golgi network IDA
IDA: Inferred from direct assay
19838196 MGI
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
34338405 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

reticulophagy regulator 1

  • family with sequence similarity 134, member B

  • protein FAM134B

  • reticulophagy receptor 1

  • reticulophagy receptor Fam134b

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11859 RETREG1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Retreg1 NCBI NCBI:54463