2. Gene
  3. Psenen - presenilin enhancer gamma secretase subunit Gene

Psenen - presenilin enhancer gamma secretase subunit Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Pen2; Pen-2; 1700023M09Rik

Gene ID: 66340 | Gene type: protein coding

About Psenen

Summary

Enables endopeptidase activator activity. Involved in positive regulation of endopeptidase activity and protein processing. Acts upstream of or within Notch receptor processing. Part of gamma-secretase complex. Is expressed in early tubule; female associated reproductive structure; male associated reproductive structure; ovary; and testis. Human ortholog(s) of this gene implicated in hidradenitis suppurativa. Orthologous to human PSENEN (presenilin enhancer, gamma-secretase subunit). [provided by Alliance of Genome Resources, Apr 2022]

Psenen Products(3)

mRNA Protein Name
NM_001364016.1 NP_001350945.1 gamma-secretase subunit PEN-2
NM_001364017.1 NP_001350946.1 gamma-secretase subunit PEN-2
NM_025498.3 NP_079774.1 gamma-secretase subunit PEN-2
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables endopeptidase activator activity IMP
IMP: Inferred from mutant phenotype
12522139 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
15474363 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within Notch receptor processing IMP
IMP: Inferred from mutant phenotype
20130175 MGI
involved in positive regulation of endopeptidase activity IMP
IMP: Inferred from mutant phenotype
12522139 MGI
involved in protein processing IMP
IMP: Inferred from mutant phenotype
12522139 MGI
Cellular Component GO Annotation Evidence Reference Source
part of gamma-secretase complex IDA
IDA: Inferred from direct assay
16371134 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

gamma-secretase subunit PEN-2

presenilin enhancer 2 homolog

presenilin enhancer protein 2

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS11278 PSENEN Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Psenen NCBI NCBI:55851