Edem3 - ER degradation enhancer, mannosidase alpha-like 3 Gene

Also Known as 2310050N11Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 66967

Summary

Enables mannosyl-oligosaccharide 1,2-alpha-mannosidase activity. Involved in mannose trimming involved in glycoprotein ERAD pathway. Acts upstream of or within glycoprotein catabolic process and proteasome-mediated ubiquitin-dependent protein catabolic process. Located in endoplasmic reticulum lumen. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation type II. Orthologous to human EDEM3 (ER degradation enhancing alpha-mannosidase like protein 3). [provided by Alliance of Genome Resources, Apr 2022]

Edem3 Products (3)

mRNA Protein Name
NM_001039644.2 NP_001034733.2 ER degradation-enhancing alpha-mannosidase-like protein 3 isoform 1 precursor
NM_001311165.1 NP_001298094.1 ER degradation-enhancing alpha-mannosidase-like protein 3 isoform 2 precursor
NM_001311166.1 NP_001298095.1 ER degradation-enhancing alpha-mannosidase-like protein 3 isoform 3 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables mannosyl-oligosaccharide 1,2-alpha-mannosidase activity IDA
IDA: Inferred from direct assay
16431915 MGI
Biological Process GO Annotation Evidence References Source
involved in ERAD pathway IDA
IDA: Inferred from direct assay
16431915 MGI
acts upstream of or within glycoprotein catabolic process IDA
IDA: Inferred from direct assay
16431915 MGI
involved in mannoprotein catabolic process IDA
IDA: Inferred from direct assay
16431915 MGI
acts upstream of or within proteasome-mediated ubiquitin-dependent protein catabolic process IDA
IDA: Inferred from direct assay
16431915 MGI
Cellular Component GO Annotation Evidence References Source
located in endoplasmic reticulum lumen IDA
IDA: Inferred from direct assay
16431915 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

ER degradation-enhancing alpha-mannosidase-like protein 3

  • ER degradation-enhancing alpha-mannosidase-like 3

  • alpha-1,2-mannosidase EDEM3

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04159 EDEM3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22479 Edem3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29002 Edem3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Edem3 NCBI NCBI:80267