Plin5 - perilipin 5 Gene

Mus musculus

Also known as MLDP; Lsdp5; PAT-1; 2310076L09Rik

Gene ID: 66968 | Gene type: protein coding

About Plin5

Summary

Enables identical protein binding activity and Lipase binding activity. Involved in several processes, including negative regulation of peroxisome proliferator activated receptor signaling pathway; positive regulation of sequestering of triglyceride; and regulation of lipid metabolic process. Located in cytosol and lipid droplet. Orthologous to human PLIN5 (perilipin 5). [provided by Alliance of Genome Resources, Apr 2022]

Plin5 Products(2)

mRNA	Protein	Name
NM_001077348.1	NP_001070816.1	perilipin-5
NM_025874.3	NP_080150.2	perilipin-5

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	21148142	MGI
enables lipase binding	IPI IPI: Inferred from physical interaction	19717842	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	21148142	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in lipid droplet organization	IMP IMP: Inferred from mutant phenotype	22532565	MGI
involved in lipid storage	IDA IDA: Inferred from direct assay	22675471	MGI
involved in lipid storage	IMP IMP: Inferred from mutant phenotype	21148142	MGI
involved in mitochondrion localization	IMP IMP: Inferred from mutant phenotype	21885430	MGI
involved in negative regulation of fatty acid beta-oxidation	IDA IDA: Inferred from direct assay	21885430	MGI
involved in negative regulation of fatty acid beta-oxidation	IMP IMP: Inferred from mutant phenotype	22532565	MGI
involved in negative regulation of lipase activity	IMP IMP: Inferred from mutant phenotype	22532565	MGI
involved in negative regulation of lipid catabolic process	IDA IDA: Inferred from direct assay	21885430	MGI
involved in negative regulation of peroxisome proliferator activated receptor signaling pathway	IDA IDA: Inferred from direct assay	22675471	MGI
involved in negative regulation of reactive oxygen species metabolic process	IMP IMP: Inferred from mutant phenotype	22532565	MGI
involved in negative regulation of triglyceride catabolic process	IDA IDA: Inferred from direct assay	22675471	MGI
involved in positive regulation of fatty acid beta-oxidation	IDA IDA: Inferred from direct assay	17130488	MGI
involved in positive regulation of sequestering of triglyceride	IDA IDA: Inferred from direct assay	22675471	MGI
involved in positive regulation of triglyceride biosynthetic process	IDA IDA: Inferred from direct assay	17130488	MGI
involved in positive regulation of triglyceride biosynthetic process	IMP IMP: Inferred from mutant phenotype	22532565	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	19717842	MGI
located in cytosol	IDA IDA: Inferred from direct assay	16571721	MGI
colocalizes with lipid droplet	IDA IDA: Inferred from direct assay	17130488	MGI
located in lipid droplet	IDA IDA: Inferred from direct assay	16571721	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

perilipin-5

lipid droplet associated protein	lipid droplet-associated protein PAT-1
lipid storage droplet protein 5	myocardial LD protein

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-111953	SR-4559		98.81%	Unkown
HY-111952	SR-4995		98.26%	Unkown
HY-RS10710	PLIN5 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Plin5	NCBI	NCBI:440503

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