Rnaseh2b - ribonuclease H2, subunit B Gene

Also Known as Dleu8; 1110019N06Rik; 2610207P08Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 67153

Summary

Acts upstream of or within several processes, including in utero embryonic development; positive regulation of fibroblast proliferation; and regulation of cell cycle phase transition. Part of ribonuclease H2 complex. Is expressed in several structures, including brain; gut; hemolymphoid system; skin; and testis. Human ortholog(s) of this gene implicated in Aicardi-Goutieres syndrome. Orthologous to human RNASEH2B (ribonuclease H2 subunit B). [provided by Alliance of Genome Resources, Apr 2022]

Rnaseh2b Products (1)

mRNA Protein Name
NM_026001.3 NP_080277.1 ribonuclease H2 subunit B

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
acts upstream of fibroblast proliferation IMP
IMP: Inferred from mutant phenotype
22802351 MGI
acts upstream of gene expression IMP
IMP: Inferred from mutant phenotype
22802351 MGI
acts upstream of or within in utero embryonic development IMP
IMP: Inferred from mutant phenotype
22802351 MGI
acts upstream of or within negative regulation of gene expression IMP
IMP: Inferred from mutant phenotype
22802351 MGI
acts upstream of or within positive regulation of fibroblast proliferation IMP
IMP: Inferred from mutant phenotype
22802351 MGI
acts upstream of or within regulation of DNA damage checkpoint IMP
IMP: Inferred from mutant phenotype
22802351 MGI
acts upstream of or within regulation of G2/M transition of mitotic cell cycle IMP
IMP: Inferred from mutant phenotype
22802351 MGI
acts upstream of or within ribonucleotide metabolic process IMP
IMP: Inferred from mutant phenotype
22802351 MGI
Cellular Component GO Annotation Evidence References Source
part of ribonuclease H2 complex IDA
IDA: Inferred from direct assay
19923215 MGI
part of ribonuclease H2 complex IPI
IPI: Inferred from physical interaction
19923215 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

ribonuclease H2 subunit B

  • RNase H2 subunit B

  • deleted in lymphocytic leukemia 8 homolog

  • ribonuclease HI subunit B

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12026 RNASEH2B Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Rnaseh2b NCBI NCBI:79621