Dram2 - DNA-damage regulated autophagy modulator 2 Gene

Also Known as Tmem77; 2010305N14Rik; 2610318G18Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 67171

Summary

Involved in photoreceptor cell maintenance. Located in apical plasma membrane and photoreceptor inner segment. Is expressed in several structures, including alimentary system; eye; genitourinary system; hemolymphoid system gland; and nervous system. Human ortholog(s) of this gene implicated in cone-rod dystrophy. Orthologous to human DRAM2 (DNA damage regulated Autophagy modulator 2). [provided by Alliance of Genome Resources, Apr 2022]

Dram2 Products (4)

mRNA Protein Name
NM_001025582.2 NP_001020753.1 DNA damage-regulated autophagy modulator protein 2 isoform 1
NM_001286986.1 NP_001273915.1 DNA damage-regulated autophagy modulator protein 2 isoform 2
NM_001286987.1 NP_001273916.1 DNA damage-regulated autophagy modulator protein 2 isoform 2
NM_026013.3 NP_080289.1 DNA damage-regulated autophagy modulator protein 2 isoform 2

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
acts upstream of or within cell population proliferation IMP
IMP: Inferred from mutant phenotype
37691820 MGI
acts upstream of or within phloem or xylem histogenesis IMP
IMP: Inferred from mutant phenotype
37691820 MGI
acts upstream of or within photoreceptor cell maintenance IMP
IMP: Inferred from mutant phenotype
37691820 MGI
involved in photoreceptor cell maintenance IMP
IMP: Inferred from mutant phenotype
25983245 MGI
acts upstream of or within retina development in camera-type eye IMP
IMP: Inferred from mutant phenotype
37691820 MGI
Cellular Component GO Annotation Evidence References Source
located in apical plasma membrane IDA
IDA: Inferred from direct assay
25983245 MGI
located in photoreceptor inner segment IDA
IDA: Inferred from direct assay
25983245 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

DNA damage-regulated autophagy modulator protein 2

  • VDNA-damage regulated autophagy modulator 2

  • transmembrane protein 77

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03988 DRAM2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Dram2 NCBI NCBI:128338