Agtpbp1 - ATP/GTP binding protein 1 Gene

Mus musculus

Also known as pcd; CCP1; Nna1; atms; nmf243; 1700020N17Rik; 2310001G17Rik; 2900054O13Rik; 4930445M19Rik; 5730402G09Rik

Gene ID: 67269 | Gene type: protein coding

About Agtpbp1

Summary

Enables metallocarboxypeptidase activity and tubulin binding activity. Involved in several processes, including nervous system development; neuromuscular process; and protein deglutamylation. Acts upstream of or within several processes, including adult walking behavior; axonal transport of mitochondrion; and central nervous system neuron differentiation. Located in cytosol; mitochondrion; and nucleus. Is expressed in central nervous system; dorsal root ganglion; and retina. Used to study retinitis pigmentosa. Orthologous to human AGTPBP1 (ATP/GTP binding Carboxypeptidase 1). [provided by Alliance of Genome Resources, Apr 2022]

Agtpbp1 Products(6)

mRNA	Protein	Name
NM_001048008.2	NP_001041473.1	cytosolic carboxypeptidase 1 isoform 2
NM_001284218.1	NP_001271147.1	cytosolic carboxypeptidase 1 isoform 2
NM_001284219.1	NP_001271148.1	cytosolic carboxypeptidase 1 isoform 3
NM_001284221.2	NP_001271150.1	cytosolic carboxypeptidase 1 isoform 4
NM_001377097.1	NP_001364026.1	cytosolic carboxypeptidase 1 isoform 1
NM_023328.3	NP_075817.2	cytosolic carboxypeptidase 1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables metallocarboxypeptidase activity	IDA IDA: Inferred from direct assay	21074048	MGI
enables metallocarboxypeptidase activity	IMP IMP: Inferred from mutant phenotype	21074048	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	21074048	MGI
enables tubulin binding	IDA IDA: Inferred from direct assay	21074048	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in C-terminal protein deglutamylation	IDA IDA: Inferred from direct assay	21074048	MGI
involved in C-terminal protein deglutamylation	IMP IMP: Inferred from mutant phenotype	21074048	MGI
acts upstream of or within adult walking behavior	IMP IMP: Inferred from mutant phenotype	16952463	MGI
acts upstream of or within anterograde axonal transport of mitochondrion	IGI IGI: Inferred from genetic interaction	30420556	MGI
acts upstream of or within axonal transport	IGI IGI: Inferred from genetic interaction	30420556	MGI
acts upstream of or within central nervous system neuron development	IGI IGI: Inferred from genetic interaction	30420556	MGI
acts upstream of or within cerebellar Purkinje cell differentiation	IGI IGI: Inferred from genetic interaction	30420556	MGI
acts upstream of or within cerebellar Purkinje cell differentiation	IMP IMP: Inferred from mutant phenotype	10630211	MGI
involved in cerebellar Purkinje cell differentiation	IMP IMP: Inferred from mutant phenotype	11884758	MGI
acts upstream of or within cerebellar Purkinje cell layer development	IMP IMP: Inferred from mutant phenotype	21052544	MGI
acts upstream of or within cerebellum development	IMP IMP: Inferred from mutant phenotype	7891151	MGI
involved in eye photoreceptor cell differentiation	IMP IMP: Inferred from mutant phenotype	16465590	MGI
involved in mitochondrion organization	IMP IMP: Inferred from mutant phenotype	20620870	MGI
acts upstream of or within negative regulation of cell population proliferation	IGI IGI: Inferred from genetic interaction	29593216	MGI
acts upstream of or within negative regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	29593216	MGI
acts upstream of or within neuromuscular process	IGI IGI: Inferred from genetic interaction	10630211	MGI
involved in neuromuscular process	IMP IMP: Inferred from mutant phenotype	11884758	MGI
involved in olfactory bulb development	IMP IMP: Inferred from mutant phenotype	11884758	MGI
acts upstream of or within positive regulation of ubiquitin-dependent protein catabolic process	IMP IMP: Inferred from mutant phenotype	29593216	MGI
acts upstream of or within protein deglutamylation	IGI IGI: Inferred from genetic interaction	30420556	MGI
acts upstream of or within protein deglutamylation	IMP IMP: Inferred from mutant phenotype	29593216	MGI
involved in protein side chain deglutamylation	IDA IDA: Inferred from direct assay	21074048	MGI
involved in protein side chain deglutamylation	IMP IMP: Inferred from mutant phenotype	21074048	MGI
acts upstream of or within retina development in camera-type eye	IMP IMP: Inferred from mutant phenotype	21052544	MGI
acts upstream of or within retrograde axonal transport of mitochondrion	IGI IGI: Inferred from genetic interaction	30420556	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	11083920	MGI
located in cytosol	IDA IDA: Inferred from direct assay	17244818	MGI
located in mitochondrion	IDA IDA: Inferred from direct assay	20620870	MGI
located in nucleus	IDA IDA: Inferred from direct assay	11083920	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

cytosolic carboxypeptidase 1

Purkinje cell degeneration	nervous system nuclear protein induced by axotomy protein 1
nuclear ATP/GTP-binding protein	protein deglutamylase CCP1

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00467	AGTPBP1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Agtpbp1	NCBI	NCBI:23287

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