Agtpbp1 - ATP/GTP binding protein 1 Gene

Also Known as pcd; CCP1; Nna1; atms; nmf243; 1700020N17Rik; 2310001G17Rik; 2900054O13Rik; 4930445M19Rik; 5730402G09Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 67269

Summary

Enables metallocarboxypeptidase activity and tubulin binding activity. Involved in several processes, including nervous system development; neuromuscular process; and protein deglutamylation. Acts upstream of or within several processes, including adult walking behavior; axonal transport of mitochondrion; and central nervous system neuron differentiation. Located in cytosol; mitochondrion; and nucleus. Is expressed in central nervous system; dorsal root ganglion; and retina. Used to study retinitis pigmentosa. Orthologous to human AGTPBP1 (ATP/GTP binding Carboxypeptidase 1). [provided by Alliance of Genome Resources, Apr 2022]

Agtpbp1 Products (6)

mRNA Protein Name
NM_001048008.2 NP_001041473.1 cytosolic carboxypeptidase 1 isoform 2
NM_001284218.1 NP_001271147.1 cytosolic carboxypeptidase 1 isoform 2
NM_001284219.1 NP_001271148.1 cytosolic carboxypeptidase 1 isoform 3
NM_001284221.2 NP_001271150.1 cytosolic carboxypeptidase 1 isoform 4
NM_001377097.1 NP_001364026.1 cytosolic carboxypeptidase 1 isoform 1
NM_023328.3 NP_075817.2 cytosolic carboxypeptidase 1 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables metallocarboxypeptidase activity IDA
IDA: Inferred from direct assay
21074048 MGI
enables metallocarboxypeptidase activity IMP
IMP: Inferred from mutant phenotype
21074048 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
21074048 MGI
enables tubulin binding IDA
IDA: Inferred from direct assay
21074048 MGI
Biological Process GO Annotation Evidence References Source
involved in C-terminal protein deglutamylation IDA
IDA: Inferred from direct assay
21074048 MGI
involved in C-terminal protein deglutamylation IMP
IMP: Inferred from mutant phenotype
21074048 MGI
acts upstream of or within adult walking behavior IMP
IMP: Inferred from mutant phenotype
16952463 MGI
acts upstream of or within anterograde axonal transport of mitochondrion IGI
IGI: Inferred from genetic interaction
30420556 MGI
acts upstream of or within axonal transport IGI
IGI: Inferred from genetic interaction
30420556 MGI
acts upstream of or within central nervous system neuron development IGI
IGI: Inferred from genetic interaction
30420556 MGI
acts upstream of or within cerebellar Purkinje cell differentiation IGI
IGI: Inferred from genetic interaction
30420556 MGI
acts upstream of or within cerebellar Purkinje cell differentiation IMP
IMP: Inferred from mutant phenotype
10630211 MGI
involved in cerebellar Purkinje cell differentiation IMP
IMP: Inferred from mutant phenotype
11884758 MGI
acts upstream of or within cerebellar Purkinje cell layer development IMP
IMP: Inferred from mutant phenotype
21052544 MGI
acts upstream of or within cerebellum development IMP
IMP: Inferred from mutant phenotype
7891151 MGI
involved in eye photoreceptor cell differentiation IMP
IMP: Inferred from mutant phenotype
16465590 MGI
involved in mitochondrion organization IMP
IMP: Inferred from mutant phenotype
20620870 MGI
acts upstream of or within negative regulation of cell population proliferation IGI
IGI: Inferred from genetic interaction
29593216 MGI
acts upstream of or within negative regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
29593216 MGI
acts upstream of or within neuromuscular process IGI
IGI: Inferred from genetic interaction
10630211 MGI
involved in neuromuscular process IMP
IMP: Inferred from mutant phenotype
11884758 MGI
involved in olfactory bulb development IMP
IMP: Inferred from mutant phenotype
11884758 MGI
acts upstream of or within positive regulation of ubiquitin-dependent protein catabolic process IMP
IMP: Inferred from mutant phenotype
29593216 MGI
acts upstream of or within protein deglutamylation IGI
IGI: Inferred from genetic interaction
30420556 MGI
acts upstream of or within protein deglutamylation IMP
IMP: Inferred from mutant phenotype
29593216 MGI
involved in protein side chain deglutamylation IDA
IDA: Inferred from direct assay
21074048 MGI
involved in protein side chain deglutamylation IMP
IMP: Inferred from mutant phenotype
21074048 MGI
acts upstream of or within retina development in camera-type eye IMP
IMP: Inferred from mutant phenotype
21052544 MGI
acts upstream of or within retrograde axonal transport of mitochondrion IGI
IGI: Inferred from genetic interaction
30420556 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
11083920 MGI
located in cytosol IDA
IDA: Inferred from direct assay
17244818 MGI
located in mitochondrion IDA
IDA: Inferred from direct assay
20620870 MGI
located in nucleus IDA
IDA: Inferred from direct assay
11083920 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

cytosolic carboxypeptidase 1

  • Purkinje cell degeneration

  • nervous system nuclear protein induced by axotomy protein 1

  • nuclear ATP/GTP-binding protein

  • protein deglutamylase CCP1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00467 AGTPBP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Agtpbp1 NCBI NCBI:23287