Tespa1 - thymocyte expressed, positive selection associated 1 Gene

Also Known as Itprid3; 5830405N20Rik; A430001F24Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 67596

Summary

Enables Phospholipase binding activity. Involved in several processes, including COP9 signalosome assembly; positive regulation of T cell differentiation in thymus; and positive regulation of T cell receptor signaling pathway. Acts upstream of or within TCR signalosome assembly. Located in cytoplasm. Part of TCR signalosome. Is expressed in testis; thymus; and thymus primordium. Orthologous to human TESPA1 (thymocyte expressed, positive selection associated 1). [provided by Alliance of Genome Resources, Apr 2022]

Tespa1 Products (1)

mRNA	Protein	Name
NM_183264.4	NP_899087.2	protein TESPA1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables phospholipase binding	IPI IPI: Inferred from physical interaction	28598420	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	28598420	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in COP9 signalosome assembly	IMP IMP: Inferred from mutant phenotype	22561606	MGI
acts upstream of T cell differentiation in thymus	IDA IDA: Inferred from direct assay	28598420	MGI
acts upstream of T cell differentiation in thymus	IMP IMP: Inferred from mutant phenotype	28598420	MGI
acts upstream of or within TCR signalosome assembly	IMP IMP: Inferred from mutant phenotype	28598420	MGI
involved in positive regulation of T cell differentiation in thymus	IMP IMP: Inferred from mutant phenotype	22561606	MGI
involved in positive regulation of T cell receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	22561606	MGI
involved in protein localization	IDA IDA: Inferred from direct assay	28598420	MGI
involved in protein localization	IMP IMP: Inferred from mutant phenotype	28598420	MGI
acts upstream of regulation of T cell receptor signaling pathway	IDA IDA: Inferred from direct assay	28598420	MGI
acts upstream of regulation of T cell receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	28598420	MGI

Cellular Component GO Annotation	Evidence	References	Source
part of TCR signalosome	IDA IDA: Inferred from direct assay	28598420	MGI
part of TCR signalosome	IMP IMP: Inferred from mutant phenotype	28598420	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	22561606	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
protein TESPA1	thymocyte-expressed positive selection-associated protein 1

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14383	TESPA1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Tespa1	NCBI	NCBI:9840