Trpm7 - transient receptor potential cation channel, subfamily M, member 7 Gene

Also Known as Chak; Ltrpc7; LTrpC-7; Trp-plik

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 679906

Summary

Enables Calcium Channel activity and protein kinase activity. Involved in several processes, including calcium ion transport; cellular magnesium ion homeostasis; and memory. Located in several cellular components, including neuronal cell body; synaptic vesicle membrane; and varicosity. Is integral component of membrane. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis-parkinsonism/dementia complex 1. Orthologous to human TRPM7 (transient receptor potential cation channel subfamily M member 7). [provided by Alliance of Genome Resources, Apr 2022]

Trpm7 Products (1)

mRNA Protein Name
NM_053705.2 NP_446157.2 transient receptor potential cation channel subfamily M member 7

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables calcium channel activity IDA
IDA: Inferred from direct assay
12904301 RGD
enables monoatomic cation channel activity IDA
IDA: Inferred from direct assay
11161216 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
11161216 RGD
enables protein kinase activity IDA
IDA: Inferred from direct assay
11161216 RGD
Biological Process GO Annotation Evidence References Source
involved in calcium ion transport IDA
IDA: Inferred from direct assay
12904301 RGD
involved in intracellular magnesium ion homeostasis IMP
IMP: Inferred from mutant phenotype
21487014 RGD
involved in memory IMP
IMP: Inferred from mutant phenotype
19734892 RGD
involved in positive regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
19734892 RGD
Cellular Component GO Annotation Evidence References Source
located in neuronal cell body IDA
IDA: Inferred from direct assay
18395621 RGD
located in synaptic vesicle membrane IDA
IDA: Inferred from direct assay
17088214 RGD
located in varicosity IDA
IDA: Inferred from direct assay
17088214 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

transient receptor potential cation channel subfamily M member 7

  • long transient receptor potential channel 7

  • transient receptor potential-phospholipase C-interacting kinase

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-168608 TRPM7-IN-1 Inhibitor 98.83% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Trpm7 NCBI NCBI:54822