Upf3b - UPF3 regulator of nonsense transcripts homolog B (yeast) Gene

Also Known as UPF3X; RENT3B; 5730594O13Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 68134

Summary

Predicted to enable mRNA binding activity. Predicted to be involved in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay and positive regulation of translation. Predicted to act upstream of or within response to unfolded protein. Predicted to be located in centriolar satellite; cytosol; and nucleoplasm. Predicted to be part of exon-exon junction complex. Predicted to be active in cytoplasm and nucleolus. Is expressed in several structures, including central nervous system. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability 82 and syndromic X-linked intellectual disability 14. Orthologous to human UPF3B (UPF3B regulator of nonsense mediated mRNA decay). [provided by Alliance of Genome Resources, Apr 2022]

Upf3b Products (1)

mRNA Protein Name
NM_026573.3 NP_080849.1 regulator of nonsense transcripts 3B

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
acts upstream of brain development IMP
IMP: Inferred from mutant phenotype
23821644 MGI
acts upstream of neuron projection development IMP
IMP: Inferred from mutant phenotype
23821644 MGI
acts upstream of or within nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IDA
IDA: Inferred from direct assay
23821644 MGI
acts upstream of or within nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IMP
IMP: Inferred from mutant phenotype
23821644 MGI
acts upstream of or within positive regulation of mRNA cis splicing, via spliceosome IMP
IMP: Inferred from mutant phenotype
16789828 MGI
acts upstream of positive regulation of neuron differentiation IMP
IMP: Inferred from mutant phenotype
23821644 MGI
Cellular Component GO Annotation Evidence References Source
located in neuronal cell body IDA
IDA: Inferred from direct assay
23821644 MGI
located in nucleus IDA
IDA: Inferred from direct assay
23821644 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

regulator of nonsense transcripts 3B

  • hUPF3B

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15485 UPF3B Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Upf3b NCBI NCBI:65109