Spire1 - spire type actin nucleation factor 1 Gene

Also Known as Spir-1; 6030430B19Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 68166

Summary

Predicted to enable actin binding activity. Involved in several processes, including Cytoskeleton organization; cytoskeleton-dependent cytokinesis; and positive regulation of mitochondrial fission. Acts upstream of or within Golgi vesicle transport; behavioral fear response; and dendritic spine development. Located in Golgi apparatus; cell cortex; and cytoplasmic vesicle membrane. Is integral component of mitochondrial outer membrane. Colocalizes with cleavage furrow. Is expressed in central nervous system; dorsal root ganglion; genitourinary system; liver; and spleen. Orthologous to human SPIRE1 (spire type actin nucleation factor 1). [provided by Alliance of Genome Resources, Apr 2022]

Spire1 Products (5)

mRNA	Protein	Name
NM_001403659.1	NP_001390588.1	protein spire homolog 1 isoform 3
NM_001403660.1	NP_001390589.1	protein spire homolog 1 isoform 4
NM_001403661.1	NP_001390590.1	protein spire homolog 1 isoform 5
NM_176832.2	NP_789802.1	protein spire homolog 1 isoform 2
NM_194355.3	NP_919336.2	protein spire homolog 1 isoform 1

Gene Ontology

Biological Process
Cellular Component

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within Golgi vesicle transport	IDA IDA: Inferred from direct assay	11747823	MGI
involved in actin cytoskeleton organization	IMP IMP: Inferred from mutant phenotype	21620703	MGI
acts upstream of or within behavioral fear response	IMP IMP: Inferred from mutant phenotype	24345451	MGI
involved in cleavage furrow formation	IMP IMP: Inferred from mutant phenotype	21620703	MGI
acts upstream of or within dendritic spine development	IMP IMP: Inferred from mutant phenotype	24345451	MGI
involved in establishment of meiotic spindle localization	IMP IMP: Inferred from mutant phenotype	21620703	MGI
involved in formin-nucleated actin cable assembly	IMP IMP: Inferred from mutant phenotype	21620703	MGI
involved in intracellular transport	IMP IMP: Inferred from mutant phenotype	21983562	MGI
involved in polar body extrusion after meiotic divisions	IMP IMP: Inferred from mutant phenotype	21620703	MGI
involved in vesicle-mediated transport	IMP IMP: Inferred from mutant phenotype	21983562	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in Golgi apparatus	IDA IDA: Inferred from direct assay	11747823	MGI
located in cell cortex	IDA IDA: Inferred from direct assay	21983562	MGI
colocalizes with cleavage furrow	IDA IDA: Inferred from direct assay	21620703	MGI
located in cytoplasmic vesicle membrane	IDA IDA: Inferred from direct assay	21983562	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
protein spire homolog 1	spire homolog 1

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13687	SPIRE1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Spire1	NCBI	NCBI:56907