2. Gene
  3. Spire1 - spire type actin nucleation factor 1 Gene

Spire1 - spire type actin nucleation factor 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Spir-1; 6030430B19Rik

Gene ID: 68166 | Gene type: protein coding

About Spire1

Summary

Predicted to enable actin binding activity. Involved in several processes, including Cytoskeleton organization; cytoskeleton-dependent cytokinesis; and positive regulation of mitochondrial fission. Acts upstream of or within Golgi vesicle transport; behavioral fear response; and dendritic spine development. Located in Golgi apparatus; cell cortex; and cytoplasmic vesicle membrane. Is integral component of mitochondrial outer membrane. Colocalizes with cleavage furrow. Is expressed in central nervous system; dorsal root ganglion; genitourinary system; liver; and spleen. Orthologous to human SPIRE1 (spire type actin nucleation factor 1). [provided by Alliance of Genome Resources, Apr 2022]

Spire1 Products(5)

mRNA Protein Name
NM_001403659.1 NP_001390588.1 protein spire homolog 1 isoform 3
NM_001403660.1 NP_001390589.1 protein spire homolog 1 isoform 4
NM_001403661.1 NP_001390590.1 protein spire homolog 1 isoform 5
NM_176832.2 NP_789802.1 protein spire homolog 1 isoform 2
NM_194355.3 NP_919336.2 protein spire homolog 1 isoform 1
Gene Ontology
  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within Golgi vesicle transport IDA
IDA: Inferred from direct assay
11747823 MGI
involved in actin cytoskeleton organization IMP
IMP: Inferred from mutant phenotype
21620703 MGI
acts upstream of or within behavioral fear response IMP
IMP: Inferred from mutant phenotype
24345451 MGI
involved in cleavage furrow formation IMP
IMP: Inferred from mutant phenotype
21620703 MGI
acts upstream of or within dendritic spine development IMP
IMP: Inferred from mutant phenotype
24345451 MGI
involved in establishment of meiotic spindle localization IMP
IMP: Inferred from mutant phenotype
21620703 MGI
involved in formin-nucleated actin cable assembly IMP
IMP: Inferred from mutant phenotype
21620703 MGI
involved in intracellular transport IMP
IMP: Inferred from mutant phenotype
21983562 MGI
involved in polar body extrusion after meiotic divisions IMP
IMP: Inferred from mutant phenotype
21620703 MGI
involved in vesicle-mediated transport IMP
IMP: Inferred from mutant phenotype
21983562 MGI
Cellular Component GO Annotation Evidence Reference Source
located in Golgi apparatus IDA
IDA: Inferred from direct assay
11747823 MGI
located in cell cortex IDA
IDA: Inferred from direct assay
21983562 MGI
colocalizes with cleavage furrow IDA
IDA: Inferred from direct assay
21620703 MGI
located in cytoplasmic vesicle membrane IDA
IDA: Inferred from direct assay
21983562 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

protein spire homolog 1

spire homolog 1

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS13687 SPIRE1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Spire1 NCBI NCBI:56907